ArticleJournal of functional biomaterials2024
Sequential Bone Repair in Rabbit Sinus Lifts Using Bio-Oss and Hyaluronic Acid-Polynucleotide Gel (Regenfast).
Article in Journal of functional biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Comparative Histological and Histomorphometric Analysis of Xenografts and Synthetic Biomaterials in Rabbit Sinus Floor Elevation.Journal of functional biomaterials · 2026Article
- The Role of Biologically Active Materials in Peri-Implant Diseases.Journal of clinical medicine · 2026Review
- Assembly of bioinspired multifunctional microspheres for enhanced alveolar bone regeneration.Bioactive materials · 2026Article
- Emerging Biomaterials for Maxillary Sinus Augmentation: From In Vitro Insights to In Vivo Clinical Translation.Materials (Basel, Switzerland) · 2026Review
- Xenograft-Induced Damage and Synechiae Formation in the Maxillary Sinus Mucosa: A Retrospective Histological Analysis in Rabbits.Dentistry journal · 2025Article
- Eighty-Four-Month Clinical Outcomes of Autologous Dentin Graft Using Tooth TransformerJournal of functional biomaterials · 2025Article
- Analysis of Implant Osseointegration, Bone Repair, and Sinus Mucosa Integrity Using Bio-OssDentistry journal · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundA comprehensive investigation to associate the use of polynucleotides and hyaluronic acid with bovine bone in maxillary sinus lift procedures in rabbits has not been performed yet. The aim was to evaluate the influence of this novel association on the processes of bone regeneration in maxillary sinus augmentation.
methodsIn this prospective, randomized, within-animal model, maxillary sinus augmentation was performed bilaterally in 12 rabbits. Deproteinized bovine bone material (DBBM) was used as filler material. A hyaluronic acid-polynucleotide gel was aggregated at the test site. Histological evaluations were performed after 2 and 10 weeks of healing.
resultsAfter 2 weeks of healing, similar amounts of new bone were observed at both the control (7.7 ± 4.3%) and test sites (8.1 ± 3.8%;
conclusionThe present study failed to demonstrate a positive effect on bone formation when incorporating hyaluronic acid-polynucleotide gel (Regenfast) into a xenograft for maxillary sinus augmentation. Additionally, the use of this gel did not mitigate the occurrence of thinned mucosa or reduce the risk of subsequent sinus mucosa perforation.
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Registered trials
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