Evidence map›Paper›PMID 39728108›Full record

ArticleMarine drugs2024

A Lucknolide Derivative Induces Mitochondrial ROS-Mediated G2/M Arrest and Apoptotic Cell Death in B16F10 Mouse Melanoma Cells.

Jae Hyeop Lee, Byeoung-Kyu Choi, Minsoo Kim, Hee Jae Shin, Sun Joo Park

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Marine natural products.Natural product reports · 2026
    Review
  4. Review
  5. Anti-Angiogenic Potential of MarineMolecules (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jae Hyeop LeeBB21 Plus Program, Department of Chemistry, Pukyong National University, Busan 48513, Republic of Korea.
Byeoung-Kyu ChoiDepartment of Bio-Convergence Engineering, Dongyang Mirae University, Seoul 08221, Republic of Korea.
Minsoo KimLaboratory of Integrative Molecular Medicine, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto-shi 606-8501, Japan.ORCID 0000-0001-8536-8653
Hee Jae ShinMarine Natural Products Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Republic of Korea.ORCID 0000-0002-5952-5325
Sun Joo ParkBB21 Plus Program, Department of Chemistry, Pukyong National University, Busan 48513, Republic of Korea.ORCID 0000-0002-3458-8418

Funding

Pukyong National University 2023
6 · The paper itself

Abstract

Melanoma is an aggressive skin cancer with a high risk of cancer-related deaths, and inducing apoptosis in melanoma cells is a promising therapeutic strategy. This study investigates the anti-tumor potential of a novel lucknolide derivative LA-UC as a therapeutic candidate for melanoma. Lucknolide A (LA), a tricyclic ketal-lactone metabolite isolated from marine-derived

Indexed as

ApoptosisG2 Phase Cell Cycle CheckpointsMelanoma, ExperimentalMitochondriaReactive Oxygen SpeciesAnimalsAntineoplastic AgentsCell Line, TumorCell ProliferationCyclin B1DNA DamageLactonesMelanomaMembrane Potential, MitochondrialMiceSkin NeoplasmsAntineoplastic AgentsCyclin B1LactonesReactive Oxygen Speciesanti-tumorapoptosislucknolide derivativemarine Streptomycesmelanomamitochondrial ROS

Identifiers

PMID39728108
PMCPMC11677583

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.