Evidence map›Paper›PMID 39728024›Full record

ArticleMovement disorders clinical practice2025

Rapid Cognitive Deterioration in Progressive Supranuclear Palsy: A 1-Year Follow-Up Study.

Xin-Yi Li, Yu-Jie Yang, Fang-Yang Jiao, Gan Tang, Ming-Jia Chen, Rui-Xin Yao, Yi-Xin Zhao, Xiao-Niu Liang, Bo Shen, Yi-Min Sun and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Differences in neuropsychological performance across clinical variants of progressive supranuclear palsy.Journal of the International Neuropsychological Society : JINS · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xin-Yi LiDepartment of Neurology, National Clinical Research Center for Aging and Medicine, & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-6353-4825
Yu-Jie YangFundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.
Fang-Yang JiaoPET Center, Huashan Hospital, Fudan University, Shanghai, China.
Gan TangDepartment of Neurology, National Clinical Research Center for Aging and Medicine, & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0009-0001-0494-3597
Ming-Jia ChenDepartment of Neurology, National Clinical Research Center for Aging and Medicine, & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Rui-Xin YaoDepartment of Neurology, National Clinical Research Center for Aging and Medicine, & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Yi-Xin ZhaoDepartment of Neurology, National Clinical Research Center for Aging and Medicine, & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Xiao-Niu LiangDepartment of Neurology, National Clinical Research Center for Aging and Medicine, & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-4542-2202
Bo ShenDepartment of Neurology, National Clinical Research Center for Aging and Medicine, & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Yi-Min SunDepartment of Neurology, National Clinical Research Center for Aging and Medicine, & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Jian-Jun WuDepartment of Neurology, National Clinical Research Center for Aging and Medicine, & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Jian WangDepartment of Neurology, National Clinical Research Center for Aging and Medicine, & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-2748-395X
Feng-Tao LiuDepartment of Neurology, National Clinical Research Center for Aging and Medicine, & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-7688-1631
Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI)

Funding

Clinical Research Project Supported by Huashan Hospital, Fudan University 2023-YN008National clinical key specialty construction project of China Z155080000004National Health Commission of People's Republic of China Pro20211231084249000238National Natural Science Foundation of China 81701250National Natural Science Foundation of China 82171252National Natural Science Foundation of China 82171421National Natural Science Foundation of China 82371266National Natural Science Foundation of China 91949118Shanghai Municipal Science and Technology Major Project 2018SHZDZX01Shanghai Municipal Science and Technology Major Project 21S31902200Shanghai Research Center of Rehabilitation Medicine (Top Priority Research Center of Shanghai) 2023ZZ02027
6 · The paper itself

Abstract

backgroundNowadays, cognitive impairment has been characterized as one of the most vital clinical symptoms in progressive supranuclear palsy (PSP).

objectivesBased on a relatively large cohort, we aimed to show the cognitive deterioration in different PSP subtypes during 1-year follow-up and investigate potential contributors for disease prognosis.

methodsOne hundred seventeen patients from Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI) cohort underwent neuropsychological tests and 1-year follow-up, with 73 diagnosed as PSP-Richardson syndrome (PSP-RS) and 44 as PSP-non-RS. Patients were divided into normal cognition (PSP-NC), mild cognitive impairment (PSP-MCI), and PSP-dementia. Cognitive impairment and progression rates were compared between PSP-RS and PSP-non-RS, and determinants for MCI conversion to dementia were calculated by multiple cox regression.

resultsAt baseline, 30.8% of PSP patients were diagnosed as dementia, 53.0% as MCI, and only 16.2% as NC. Compared to PSP-non-RS, PSP-RS suffered more from motor symptoms and cognitive impairment. During follow-up, PSP-RS also exhibited faster disease progression in Mini-Mental State Examination and visuospatial function, with cognitive deterioration in attention and executive function, but retained in language and memory subdomains. Twenty-seven of 62 PSP-MCI patients converted to dementia during follow-up, with the diagnosis of RS subtype as the most significant contributor to conversion (hazard ration = 2.993, 95% confidence interval = 1.451, 5.232, P = 0.009).

conclusionsPatients with PSP-RS showed more severe cognitive impairment and faster decline longitudinally than patients with PSP-non-RS. Additionally, the diagnosis of RS subtype appears to be the most contributed factor for MCI conversion to dementia within just 1-year follow-up period.

Indexed as

Cognitive DysfunctionDementiaSupranuclear Palsy, ProgressiveAgedAged, 80 and overDisease ProgressionFemaleFollow-Up StudiesHumansMaleMiddle AgedNeuropsychological Testscognitive impairmentdementiafollow‐upprogressive supranuclear palsyRichardson syndrome

Identifiers

PMID39728024
PMCPMC11998687

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.