Evidence map›Paper›PMID 39727946›Full record

ArticleCurrent issues in molecular biology2024

Variable Expression of Oncogene-Induced Senescence/SASP Surrogates in HPV-Associated Precancerous Cervical Tissue.

Tareq Saleh, Nisreen Himsawi, Amani Al Rousan, Ahmad Alhesa, Mohammed El-Sadoni, Suzan Khawaldeh, Nisreen Abu Shahin, Ala' Abu Ghalioun, Bayan Shawish, Kholoud Friehat and 6 more

Abstract read
In one paragraph

Article in Current issues in molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tareq SalehDepartment of Pharmacology and Public Health, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan.ORCID 0000-0002-2878-1107
Nisreen HimsawiDepartment of Microbiology, Pathology and Forensic Medicine, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan.ORCID 0000-0003-3769-8134
Amani Al RousanKing Hussein Medical Center, Royal Medical Services, Amman 11942, Jordan.
Ahmad AlhesaDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan.
Mohammed El-SadoniKing Hussein Medical Center, Royal Medical Services, Amman 11942, Jordan.
Suzan KhawaldehDepartment of Pharmacology and Public Health, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan.
Nisreen Abu ShahinDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan.ORCID 0000-0003-3044-3569
Ala' Abu GhaliounDepartment of Microbiology, Pathology and Forensic Medicine, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan.
Bayan ShawishDepartment of Pharmacology and Public Health, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan.
Kholoud FriehatDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan.
Moureq R AlotaibiDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 12271, Saudi Arabia.
Ola Abu Al KarsanehDepartment of Microbiology, Pathology and Forensic Medicine, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan.ORCID 0000-0001-6064-2548
Anas Abu-HumaidanDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan.ORCID 0000-0003-1739-6948
Rame KhasawnehKing Hussein Medical Center, Royal Medical Services, Amman 11942, Jordan.ORCID 0000-0002-6716-2851
Ashraf I KhasawnehDepartment of Microbiology, Pathology and Forensic Medicine, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan.ORCID 0000-0001-7880-7849
Sofian Al ShboulDepartment of Pharmacology and Public Health, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan.ORCID 0000-0002-0455-4380

Funding

Hashemite University 465/83/2019
6 · The paper itself

Abstract

Oncogene-induced senescence (OIS) is a form of cellular senescence triggered by oncogenic signaling and, potentially, by infection with oncogenic viruses. The role of senescence, along with its associated secretory phenotype, in the development of cervical cancer remains unclear. Additionally, the expression of the senescence-associated secretory phenotype (SASP) has not yet been explored in cervical premalignant lesions infected by the Human Papilloma Virus (HPV). This study aimed to investigate the expression of OIS and SASP markers in HPV-infected cervical precancerous lesions. We used a set of patient-derived precancerous (

Indexed as

cervixHPVoncogene-induced senescencepremalignantSASP

Identifiers

PMID39727946
PMCPMC11727613

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.