Evidence map›Paper›PMID 39727892›Full record

ReviewBiosensors2024

Nanopipettes as a Potential Diagnostic Tool for Selective Nanopore Detection of Biomolecules.

Regina M Kuanaeva, Alexander N Vaneev, Petr V Gorelkin, Alexander S Erofeev

Abstract readReview
In one paragraph

Review in Biosensors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Regina M KuanaevaResearch Laboratory of Biophysics, National University of Science and Technology "MISIS", 119049 Moscow, Russia.
Alexander N VaneevResearch Laboratory of Biophysics, National University of Science and Technology "MISIS", 119049 Moscow, Russia.
Petr V GorelkinResearch Laboratory of Biophysics, National University of Science and Technology "MISIS", 119049 Moscow, Russia.ORCID 0000-0002-4860-9013
Alexander S ErofeevResearch Laboratory of Biophysics, National University of Science and Technology "MISIS", 119049 Moscow, Russia.

Funding

Ministry of Science and Higher Education of the Russian Federation 075-15-2022-264
6 · The paper itself

Abstract

Nanopipettes, as a class of solid-state nanopores, have evolved into universal tools in biomedicine for the detection of biomarkers and different biological analytes. Nanopipette-based methods combine high sensitivity, selectivity, single-molecule resolution, and multifunctionality. The features have significantly expanded interest in their applications for the biomolecular detection, imaging, and molecular diagnostics of real samples. Moreover, the ease of manufacturing nanopipettes, coupled with their compatibility with fluorescence and electrochemical methods, makes them ideal for portable point-of-care diagnostic devices. This review summarized the latest progress in nanopipette-based nanopore technology for the detection of biomarkers, DNA, RNA, proteins, and peptides, in particular β-amyloid or α-synuclein, emphasizing the impact of technology on molecular diagnostics. By addressing key challenges in single-molecule detection and expanding applications in diverse biological areas, nanopipettes are poised to play a transformative role in the future of personalized medicine.

Indexed as

Biosensing TechniquesNanoporesBiomarkersDNAElectrochemical TechniquesHumansProteinsRNABiomarkersDNAProteinsRNAmolecular diagnosticsnanopipettenanoporesingle moleculesolid-state nanopore

Identifiers

PMID39727892
PMCPMC11674911

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.