ReviewBiosensors2024
Advances in Surface-Enhanced Raman Spectroscopy for Urinary Metabolite Analysis: Exploiting Noble Metal Nanohybrids.
Review in Biosensors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Research progress of AI assisted nano-SERS technology in rapid identification of multi species oral pathogenic biofilms.Mikrochimica acta · 2026Review
- Review of the Current State of Optical Characterization and Design of Electronic States in Plasmonic Materials-From Noble Metals to Silverene and Goldene.Nanomaterials (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
This review examines recent advances in surface-enhanced Raman spectroscopy (SERS) for urinary metabolite analysis, focusing on the development and application of noble metal nanohybrids. We explore the diverse range of hybrid materials, including carbon-based, metal-organic-framework (MOF), silicon-based, semiconductor, and polymer-based systems, which have significantly improved SERS performance for detecting key urinary biomarkers. The principles underlying SERS enhancement in these nanohybrids are discussed, elucidating both electromagnetic and chemical enhancement mechanisms. We analyze various fabrication methods that enable precise control over nanostructure morphology, composition, and surface chemistry. The review critically evaluates the analytical performance of different hybrid systems for detecting specific urinary metabolites, considering factors such as sensitivity, selectivity, and stability. We address the analytical challenges associated with SERS-based urinary metabolite analysis, including sample preparation, matrix effects, and data interpretation. Innovative solutions, such as the integration of SERS with microfluidic devices and the application of machine learning algorithms for spectral analysis, are highlighted. The potential of these advanced SERS platforms for point-of-care diagnostics and personalized medicine is discussed, along with future perspectives on wearable SERS sensors and multi-modal analysis techniques. This comprehensive overview provides insights into the current state and future directions of SERS technology for urinary metabolite detection, emphasizing its potential to revolutionize non-invasive health monitoring and disease diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.