ArticleBiomimetics (Basel, Switzerland)2024
Polyetheretherketone Double Functionalization with Bioactive Peptides Improves Human Osteoblast Response.
Article in Biomimetics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Process-Driven Optimization of FDM Porous PEEK Scaffolds for Alloplastic Bone Grafts.ACS omega · 2025Article
- Empowering Gliadin Detection: A Visible-Code Semiquantitative Lateral Flow System for Rapid and Reliable Results.Journal of agricultural and food chemistry · 2025Article
- A Comparative Finite Element Analysis of Titanium, Autogenous Bone, and Polyetheretherketone (PEEK)-Based Solutions for Mandibular Reconstruction.Materials (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
In recent years, the demand for orthopedic implants has surged due to increased life expectancy, necessitating the need for materials that better mimic the biomechanical properties of human bone. Traditional metal implants, despite their mechanical superiority and biocompatibility, often face challenges such as mismatched elastic modulus and ion release, leading to complications and implant failures. Polyetheretherketone (PEEK), a semi-crystalline polymer with an aromatic backbone, presents a promising alternative due to its adjustable elastic modulus and compatibility with bone tissue. This study explores the functionalization of sandblasted 3D-printed PEEK disks with the bioactive peptides Aoa-GBMP1α and Aoa-EAK to enhance human osteoblast response. Aoa-GBMP1α reproduces 48-69 trait of Bone Morphogenetic Protein 2 (BMP-2), whereas Aoa-EAK is a self-assembling peptide mimicking extracellular matrix (ECM) fibrous structure. Superficial characterization included X-ray photoelectron spectroscopy (XPS), white light interferometer analysis, static water contact angle (S-WCA), and force spectroscopy (AFM-FS). Biological assays demonstrated a significant increase in human osteoblast (HOB) proliferation, calcium deposition, and expression of osteogenic genes (
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Registered trials
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