Evidence map›Paper›PMID 39727715›Full record

ReviewCurrent oncology (Toronto, Ont.)2024

Challenges in Implementing Comprehensive Precision Medicine Screening for Ovarian Cancer.

Laura R Moffitt, Nazanin Karimnia, Amy L Wilson, Andrew N Stephens, Gwo-Yaw Ho, Maree Bilandzic

Abstract readReview
In one paragraph

Review in Current oncology (Toronto, Ont.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Laura R MoffittHudson Institute of Medical Research, Clayton 3168, Australia.ORCID 0000-0003-4496-2263
Nazanin KarimniaHudson Institute of Medical Research, Clayton 3168, Australia.ORCID 0009-0009-0702-2353
Amy L WilsonHudson Institute of Medical Research, Clayton 3168, Australia.ORCID 0000-0003-2048-1027
Andrew N StephensHudson Institute of Medical Research, Clayton 3168, Australia.
Gwo-Yaw HoSchool of Clinical Sciences, Monash University, Clayton 3168, Australia.ORCID 0000-0003-1195-2296
Maree BilandzicHudson Institute of Medical Research, Clayton 3168, Australia.ORCID 0000-0002-6319-1153

Funding

Ovarian Cancer Research Foundation GA-2019-20
6 · The paper itself

Abstract

Precision medicine has revolutionised targeted cancer treatments; however, its implementation in ovarian cancer remains challenging. Diverse tumour biology and extensive heterogeneity in ovarian cancer can limit the translatability of genetic profiling and contribute to a lack of biomarkers of treatment response. This review addresses the barriers in precision medicine for ovarian cancer, including obtaining adequate and representative tissue samples for analysis, developing functional and standardised screening methods, and navigating data infrastructure and management. Ethical concerns related to patient consent, data privacy and health equity are also explored. We highlight the socio-economic complexities for precision medicine and propose strategies to overcome these challenges with an emphasis on accessibility and education amongst patients and health professionals and the development of regulatory frameworks to support clinical integration. Interdisciplinary collaboration is essential to drive progress in precision medicine to improve disease management and ovarian cancer patient outcomes.

Indexed as

Early Detection of CancerOvarian NeoplasmsPrecision MedicineFemaleHumansepithelial ovarian cancergenomic screeninghigh-throughput drug screeningprecision medicinetumour heterogeneity

Identifiers

PMID39727715
PMCPMC11674382

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.