Evidence map›Paper›PMID 39727708›Full record

ArticleCurrent oncology (Toronto, Ont.)2024

STIL Overexpression Is Associated with Chromosomal Numerical Abnormalities in Non-Small-Cell Lung Carcinoma Through Centrosome Amplification.

Shunsuke Ohtsuka, Hisami Kato, Rei Ishikawa, Hirofumi Watanabe, Ryosuke Miyazaki, Shin-Ya Katsuragi, Katsuhiro Yoshimura, Hidetaka Yamada, Yasuhiro Sakai, Yusuke Inoue and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. The γ-TuRC: mastermind of multipurpose actions at the centrosome.Cellular and molecular life sciences : CMLS · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shunsuke OhtsukaDepartment of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Hisami KatoDepartment of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Rei IshikawaDepartment of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.ORCID 0000-0003-4695-809X
Hirofumi WatanabeDepartment of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Ryosuke MiyazakiDepartment of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Shin-Ya KatsuragiDepartment of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Katsuhiro YoshimuraDepartment of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Hidetaka YamadaDepartment of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.ORCID 0000-0003-4848-7201
Yasuhiro SakaiDepartment of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.ORCID 0000-0001-7210-9249
Yusuke InoueSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Yusuke TakanashiDepartment of Surgery 1, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Keigo SekiharaDepartment of Surgery 1, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.ORCID 0000-0003-4242-1199
Kazuhito FunaiDepartment of Surgery 1, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.ORCID 0000-0001-8609-3305
Haruhiko SugimuraDepartment of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.ORCID 0000-0002-0779-3088
Kazuya ShinmuraDepartment of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.ORCID 0000-0003-4963-746X

Funding

Japan Society for the Promotion of Science 16K08709
6 · The paper itself

Abstract

STIL is a regulatory protein essential for centriole biogenesis, and its dysregulation has been implicated in various diseases, including malignancies. However, its role in non-small-cell lung carcinoma (NSCLC) remains unclear. In this study, we examined STIL expression and its potential association with chromosomal numerical abnormalities (CNAs) in NSCLC using The Cancer Genome Atlas (TCGA) dataset, immunohistochemical analysis, and in vitro experiments with NSCLC cell lines designed to overexpress STIL. TCGA data revealed upregulated STIL mRNA expression in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), the two major subtypes of NSCLC. Immunohistochemical analysis of cases from our hospital (LUAD,

Indexed as

Carcinoma, Non-Small-Cell LungCentrosomeLung NeoplasmsCell Line, TumorChromosomal InstabilityChromosome AberrationsFemaleGene Expression Regulation, NeoplasticHumansIntracellular Signaling Peptides and ProteinsMaleIntracellular Signaling Peptides and ProteinsSTIL protein, humancentrosome amplificationchromosomal instabilitychromosomal numerical abnormalitylung adenocarcinomalung squamous cell carcinomanon-small-cell lung carcinomaoverexpressionSTIL

Identifiers

PMID39727708
PMCPMC11674966

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.