The Role of Frailty and Myosteatosis in Predicting All-Cause Mortality in Older Adults with Cancer.

Efthymios Papadopoulos, Andy Kin On Wong, Sharon Hiu Ching Law, Sarah Costa, Angela M Cheung, Dmitry Rozenberg, Shabbir M H Alibhai

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In one paragraph

Article in Current oncology (Toronto, Ont.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

The association between radiographic osteosarcopenia and overall mortality among older patients undergoing colorectal cancer resection.Aging clinical and experimental research · 2026
Article
Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies.Drugs & aging · 2025
Review
Skeletal muscle index, grip strength, and physical performance as predictors of severe chemotherapy toxicity among older adults with malignancy.PloS one · 2025
Article
Prognostic Significance of Myopenia, Myosteatosis, and Frailty in Older Patients With Prostate Cancer Undergoing Definitive Radiotherapy.Cancer control : journal of the Moffitt Cancer Center
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Efthymios PapadopoulosSchool of Kinesiology, Louisiana State University, Baton Rouge, LA 70803, USA.

Andy Kin On WongCentre of Excellence in Skeletal Health Assessment, Joint Department of Medical Imaging, University Health Network, Toronto, ON M5G 2C4, Canada.

Sharon Hiu Ching LawCentre of Excellence in Skeletal Health Assessment, Joint Department of Medical Imaging, University Health Network, Toronto, ON M5G 2C4, Canada.

Sarah CostaCentre of Excellence in Skeletal Health Assessment, Joint Department of Medical Imaging, University Health Network, Toronto, ON M5G 2C4, Canada.

Angela M CheungCentre of Excellence in Skeletal Health Assessment, Joint Department of Medical Imaging, University Health Network, Toronto, ON M5G 2C4, Canada.

Dmitry RozenbergToronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2C4, Canada.ORCID 0000-0001-8786-9152

Shabbir M H AlibhaiDepartment of Medicine, University Health Network, Toronto, ON M5G 2C4, Canada.ORCID 0000-0001-7815-6046

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frailty and myosteatosis are each prognostic of all-cause mortality (ACM) in patients with cancer. However, it is unclear whether myosteatosis adds value to frailty for predicting ACM. We assessed whether myosteatosis improves the predictive ability of frailty for ACM in older adults undergoing chemotherapy. This was a retrospective study of older adults (≥65 years) initiating chemotherapy between June 2015 and June 2022. Frailty was assessed using a 24-item frailty index (FI). Myosteatosis was evaluated via computed tomography scans at the third lumbar vertebra (L3).. Multivariable Cox regression and Uno's c-statistic determined the predictive performance of the FI and myosteatosis. In total, 115 participants (mean age: 77.1 years) were included. Frailty alone (adjusted hazards ratio (aHR) = 1.68, 95% confidence intervals (CIs) = 1.03-2.72,

Indexed as

FrailtyNeoplasmsAgedAged, 80 and overFemaleHumansMalePrognosisRetrospective Studiescancerfrailtymuscle densitymyosteatosisolder adultssurvival

Identifiers

PMID39727701

DOI10.3390/curroncol31120578

PMCPMC11674696

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.