Evidence map›Paper›PMID 39727685›Full record

ArticleCurrent oncology (Toronto, Ont.)2024

Personalized Ultra-Fractionated Stereotactic Adaptive Radiotherapy for Non-Small Cell Lung Cancer Using Varian Ethos Therapy System.

Vanda Leipold, Blanka Jakšić, Asmir Avdičević, Domagoj Kosmina, Hrvoje Kaučić, Ivana Alerić, Karla Schwarz, Mihaela Mlinarić, Giovanni Ursi, Adlan Čehobašić and 1 more

Abstract readCase Reports
In one paragraph

Article in Current oncology (Toronto, Ont.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vanda LeipoldSpecialty Hospital Radiochirurgia Zagreb, 10431 Sveta Nedelja, Croatia.ORCID 0000-0003-2338-8119
Blanka JakšićSpecialty Hospital Radiochirurgia Zagreb, 10431 Sveta Nedelja, Croatia.
Asmir AvdičevićSpecialty Hospital Radiochirurgia Zagreb, 10431 Sveta Nedelja, Croatia.
Domagoj KosminaSpecialty Hospital Radiochirurgia Zagreb, 10431 Sveta Nedelja, Croatia.ORCID 0000-0002-4099-9002
Hrvoje KaučićSpecialty Hospital Radiochirurgia Zagreb, 10431 Sveta Nedelja, Croatia.ORCID 0000-0002-9451-1762
Ivana AlerićSpecialty Hospital Radiochirurgia Zagreb, 10431 Sveta Nedelja, Croatia.
Karla SchwarzSchool of Medicine, University of Zagreb, 10000 Zagreb, Croatia.ORCID 0000-0001-9278-660X
Mihaela MlinarićSpecialty Hospital Radiochirurgia Zagreb, 10431 Sveta Nedelja, Croatia.ORCID 0000-0002-6362-473X
Giovanni UrsiSpecialty Hospital Radiochirurgia Zagreb, 10431 Sveta Nedelja, Croatia.
Adlan ČehobašićSpecialty Hospital Radiochirurgia Zagreb, 10431 Sveta Nedelja, Croatia.ORCID 0000-0001-8556-3280
Dragan SchwarzSpecialty Hospital Radiochirurgia Zagreb, 10431 Sveta Nedelja, Croatia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a patient treated with personalized ultra-fractionated stereotactic adaptive radiotherapy (PULSAR) for non-small cell lung cancer (NSCLC) using the adaptive Varian Ethos™ system equipped with the novel HyperSight imaging platform. Three pulses of 12 Gy were separated by a pause of four weeks during which the tumor was given enough time to respond to treatment. Only initial planning computed tomography (CT) was acquired on a CT simulator (Siemens Somatom Definition Edge), whereas other pulses were adapted using online cone beam computed tomography (CBCT) images (iCBCT Acuros reconstruction) acquired while the patient was lying on the treatment couch and delivered immediately. Significant tumor reduction was achieved between pulses, resulting in improved organs-at-risk sparing. In addition, the on-couch plan optimization based on CBCT greatly reduced the patient's stay at the clinic and the duration of treatment preparation.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsRadiosurgeryCone-Beam Computed TomographyDose Fractionation, RadiationHumansMalePrecision MedicineRadiotherapy Planning, Computer-Assistedadaptive radiotherapyHyperSightNSCLCpersonalized ultra-fractionated stereotactic adaptive radiotherapyVarian Ethos

Identifiers

PMID39727685
PMCPMC11674184

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.