Evidence map›Paper›PMID 39727681›Full record

ArticleCurrent oncology (Toronto, Ont.)2024

Brain Metastases in Gynaecologic Cancer: A Retrospective Cohort Study Evaluating Treatment Outcomes, Prognostic Factors, and Overall Survival.

Carly M Cooke, M Ege Babadagli, Hillary Wilson, Vimoj J Nair, Krystine Lupe, Shawn Malone, Laura Burgess, Wylam Faught, Rajiv Samant, Tien Le

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carly M CookeDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
M Ege BabadagliDivision of Radiation Oncology, Department of Radiology, Radiation Oncology and Medical Biophysics, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Hillary WilsonDivision of Radiation Oncology, Department of Radiology, Radiation Oncology and Medical Biophysics, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Vimoj J NairDivision of Radiation Oncology, Department of Radiology, Radiation Oncology and Medical Biophysics, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.ORCID 0000-0001-9853-5596
Krystine LupeDivision of Radiation Oncology, Department of Radiology, Radiation Oncology and Medical Biophysics, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Shawn MaloneDivision of Radiation Oncology, Department of Radiology, Radiation Oncology and Medical Biophysics, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Laura BurgessDivision of Radiation Oncology, Department of Radiology, Radiation Oncology and Medical Biophysics, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Wylam FaughtDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Rajiv SamantDivision of Radiation Oncology, Department of Radiology, Radiation Oncology and Medical Biophysics, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.ORCID 0000-0002-8757-8467
Tien LeDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: The objectives of this study were to assess survival of patients with a diagnosis of brain metastases secondary to gynaecologic malignancy and the impact of clinicopathological factors on prognosis in this population. (2) Methods: A retrospective cohort of patients with gynaecologic cancers diagnosed with brain metastases treated with radiation at a tertiary care centre from 1 January 2004 until 30 September 2023 was studied. Kaplan-Meier method and log-rank test were used to evaluate survival, and cox regression was used to identify significant predictive factors of survival. (3) Results: In total, 103 patients were included in this study. Median age at diagnosis of brain metastases was 59 (range 30-94). Median survival time following diagnosis of brain metastases was 3.6 months (range 0.4-183.8). Survival was significantly longer for patients treated with surgery combined with radiation compared to radiation alone and with stereotactic radiosurgery (SRS) compared to whole brain radiation therapy (WBRT). Cox regression revealed that primary ovarian malignancy, extracranial disease at diagnosis, and ≥3 brain metastases were associated with poorer prognosis, and complete response to prior treatment was associated with more favourable prognosis. (4) Conclusions: Data from this study will assist in providing evidence-based prognostic information to patients with gynaecologic malignancy diagnosed with brain metastases.

Indexed as

Brain NeoplasmsGenital Neoplasms, FemaleAdultAgedAged, 80 and overFemaleHumansMiddle AgedPrognosisRetrospective StudiesTreatment Outcomebrain metastasesgynaecologic malignancyradiation

Identifiers

PMID39727681
PMCPMC11674415

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.