Evidence map›Paper›PMID 39727639›Full record

ArticleDiseases (Basel, Switzerland)2024

Evidence-Based Guidance for One Health Preparedness, Prevention, and Response Strategies to Marburg Virus Disease Outbreaks.

Claude Mambo Muvunyi, Jean Claude Semuto Ngabonziza, Noella Bigirimana, Nicaise Ndembi, Emmanuel Edwar Siddig, Jean Kaseya, Ayman Ahmed

Abstract read
In one paragraph

Article in Diseases (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Marburg virus disease outbreak and response in South Ethiopia Region.International journal of emergency medicine · 2026
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  18. Genomic Evolution and Phylodynamics of the SpeciesPathogens (Basel, Switzerland) · 2024
    Review
  19. Marburg Virus: A Looming Threat Nigeria Cannot Ignore.Nigerian medical journal : journal of the Nigeria Medical Association
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Claude Mambo MuvunyiRwanda Biomedical Center (RBC), Kigali 7162, Rwanda.
Jean Claude Semuto NgabonzizaDepartment of Clinical Biology, University of Rwanda, Kigali 3900, Rwanda.ORCID 0000-0002-6075-5603
Noella BigirimanaRwanda Biomedical Center (RBC), Kigali 7162, Rwanda.
Nicaise NdembiThe Africa Centres for Disease Control and Prevention (Africa CDC), Ring Road, 16/17, Haile Garment Lafto Square, Addis Ababa P.O. Box 3243, Ethiopia.
Emmanuel Edwar SiddigUnit of Applied Medical Sciences, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum 11111, Sudan.ORCID 0000-0001-6314-7374
Jean KaseyaThe Africa Centres for Disease Control and Prevention (Africa CDC), Ring Road, 16/17, Haile Garment Lafto Square, Addis Ababa P.O. Box 3243, Ethiopia.
Ayman AhmedRwanda Biomedical Center (RBC), Kigali 7162, Rwanda.ORCID 0000-0002-9516-9508

Funding

The APCs for this were paid from grant provided by the Belgian Directorate General for Devel-opment Cooperation to institutional collaboration, Rwanda Biomedical Centre and the Institute of Tropical Medicine
6 · The paper itself

Abstract

objectivesMarburg virus disease (MVD) is on the WHO list for pandemic-prone pathogens. The current outbreak in Rwanda provides an opportunity to map outbreaks and generate information to inform policymaking, resource mobilization, and guide the implementation of cost-effective response strategies.

methodsWe synthesized available information about MVD to build holistic, up-to-date evidence to inform policymakers, public health leaders, and healthcare and public health services providers in their development and implementation of cost-effective preparedness, prevention, and control measures.

resultsWe have identified 20 outbreaks of MVD that occurred in 14 countries between 1967 and 2024; these outbreaks led to 580 confirmed cases and 423 deaths in total. We summarize the available information about the main clinical signs, diagnostic tools, primary reservoir, transmission dynamics, and case management protocol. We also document the best practices in the prevention and control of MVD outbreaks, including the implementation of a multisectoral One Health strategy for preparedness, prevention, and response to MVD outbreaks that incorporates the strict implementation of WASH and infection prevention measures, contact tracing, and the isolation of infected and suspected humans and animals, and enhances the implementation of the International Health Regulations, particularly efficient cross-country coordination.

conclusionsIn the absence of a licensed treatment or vaccine for MVD, the response strategy to MVD should focus on preventive measures, including community engagement to promote the reduction in contact between humans and reservoirs, the supportive care and isolation of patients, and proper waste management. High risk populations such as frontline responders, including healthcare providers and community health workers, should be prioritized so that they can access all currently available protection measures.

Indexed as

Africaglobal health securityhemorrhagic fevermultisectoral one health strategypandemic preparednesspandemic-prone diseasespreventionresponsezoonotic-viral infection

Identifiers

PMID39727639
PMCPMC11727285

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.