ReviewDiseases (Basel, Switzerland)2024
Corticosteroid-Induced Psychiatric Disorders: Mechanisms, Outcomes, and Clinical Implications.
Review in Diseases (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Psychiatric Symptoms Associated with Corticosteroid Use: A Systematic Review and Meta-analysis.CNS drugs · 2026Pooled it
- Corticosteroid-induced manic and/or psychotic symptoms: a systematic review.Frontiers in pharmacology · 2025Pooled it
- Sexual function and activity in young adults with a primary brain tumor-A population-based longitudinal study.Neuro-oncology practice · 2026Article
- Frequency of depression and anxiety in patients with inborn errors of immunity: a cross-sectional study.BMC psychiatry · 2026Article
- Association Between Glucocorticoid Exposure and Objective Sleep Architecture in Rheumatoid Arthritis: An Exploratory Pilot EEG Study.Journal of clinical medicine · 2026Article
- Ophthalmic and psychiatric health: the overlooked connection between ocular diseases and mental disorders.Eye (London, England) · 2026Review
- Corticosteroids in asthma and COPD: an inflammopharmacological perspective on molecular and genetic determinants.Molecular biology reports · 2026Review
- Disparities in oral glucocorticoid prescribing among patients with mental disorders: nationwide cohort study.BJPsych open · 2026Article
- Satisfaction with academic supervision among nursing postgraduate students in China: a national multicenter cross-sectional study.BMC medical education · 2026Article
- Validation of the modified transplant symptom occurrence and symptom distress scale and exploring symptom burden in Brazilian kidney transplant recipients.Scientific reports · 2026Article
- Corticosteroid-Induced neuropsychiatric manifestations: From pathophysiology to management.Psychopharmacology · 2026Review
- Corticosteroid-Induced neuropsychiatric manifestations: From pathophysiology to management.Psychopharmacology · 2026Review
- Clinical and Psychological Impact of COVID-19 on Maintenance Hemodialysis Patients: Hospitalization Burden, De Novo Anxiolytic Use, and Long-Term Survival.Medicina (Kaunas, Lithuania) · 2026Article
- Reconceptualizing bipolar disorder through an integrative biological lens: synthesis, convergence, and emerging directions.Frontiers in integrative neuroscience · 2026Review
- Psychosomatic interplay in postmenopausal osteoporosis: from neuroendocrine mechanisms to structured psychological therapies and long-term management.Frontiers in psychiatry · 2026Review
- Case Report: Corticosteroid-induced severe psychiatric manifestations in a patient with leptomeningeal metastases from lung adenocarcinoma.Frontiers in pharmacology · 2026Article
- Suicidal ideation and interrelated psychiatric disturbances in rheumatoid arthritis: Evidence from a Vietnamese cohort.PloS one · 2026Article
- Comparative Risk for Neuropsychiatric Events in Leukotriene Receptor Antagonist vs. Inhaled Corticosteroid in Children With Asthma: A Nationwide Observational Study With a Complementary Analysis Using Natural Language Processing.Pharmacoepidemiology and drug safety · 2025Observational
- Neurobiological Correlates of Coping Strategies in PTSD: The Role of IGF-1, CASP-9, nNOS, and IL-10 Based on Brief-COPE Assessment.Current issues in molecular biology · 2025Article
- Brain Tumors, AI and Psychiatry: Predicting Tumor-Associated Psychiatric Syndromes with Machine Learning and Biomarkers.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Corticosteroids are extensively used in medicine for their powerful anti-inflammatory and immunosuppressive effects. However, their psychiatric side effects-such as mood disturbances, anxiety, and psychosis-are significant yet often underappreciated. This review provides a comprehensive exploration of corticosteroid-induced psychiatric disorders, with a focus on their underlying mechanisms and clinical implications. We examine how corticosteroids influence the hypothalamic-pituitary-adrenal (HPA) axis, leading to the dysregulation of stress responses and alterations in neurotransmitter levels, particularly dopamine, serotonin, and glutamate. These changes are linked to structural abnormalities in key brain areas such as the hippocampus and amygdala, which are implicated in mood and anxiety disorders, psychosis, and conditions like post-traumatic stress disorder (PTSD) and eating disorders. This review highlights the need for healthcare providers to be vigilant in recognizing and managing corticosteroid-induced psychiatric symptoms, especially in vulnerable populations with pre-existing mental health conditions. The complex relationship between corticosteroid type, dose, duration, and mental health outcomes is explored, emphasizing the importance of personalized treatment approaches to mitigate psychiatric risks. Given the widespread use of corticosteroids, there is an urgent need for more focused research on their psychiatric side effects. This review underscores the importance of patient education and careful monitoring to ensure optimal therapeutic outcomes while minimizing mental health risks associated with corticosteroid therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.