Evidence map›Paper›PMID 39727588›Full record

ArticleGels (Basel, Switzerland)2024

Innovative Ink-Based 3D Hydrogel Bioprinted Formulations for Tissue Engineering Applications.

Ana Catarina Sousa, Grace Mcdermott, Fraser Shields, Rui Alvites, Bruna Lopes, Patrícia Sousa, Alícia Moreira, André Coelho, José Domingos Santos, Luís Atayde and 4 more

Abstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ana Catarina SousaDepartamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal.ORCID 0000-0002-8800-2195
Grace McdermottDepartment of Cell Matrix Biology & Regenerative Medicine, Faculty of Biology, Medicine & Health, The University of Manchester, Manchester M13 9PL, UK.
Fraser ShieldsDepartment of Cell Matrix Biology & Regenerative Medicine, Faculty of Biology, Medicine & Health, The University of Manchester, Manchester M13 9PL, UK.ORCID 0000-0003-3325-4181
Rui AlvitesDepartamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal.ORCID 0000-0003-1945-6377
Bruna LopesDepartamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal.
Patrícia SousaDepartamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal.ORCID 0000-0003-2531-3196
Alícia MoreiraDepartamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal.ORCID 0000-0002-1347-8789
André CoelhoDepartamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal.
José Domingos SantosAssociated Laboratory for Green Chemistry (REQUIMTE-LAQV), Departamento de Engenharia Metalúrgica e Materiais, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.ORCID 0000-0002-6871-9850
Luís AtaydeDepartamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal.ORCID 0000-0001-7668-3897
Nuno AlvesCentre for Rapid and Sustainable Product Development (CDRSP), Polytechnic Institute of Leiria, 2430-028 Marinha Grande, Portugal.ORCID 0000-0002-5016-0868
Stephen M RichardsonDepartment of Cell Matrix Biology & Regenerative Medicine, Faculty of Biology, Medicine & Health, The University of Manchester, Manchester M13 9PL, UK.ORCID 0000-0002-7637-4135
Marco DomingosDepartment of Mechanical and Aerospace Engineering, School of Engineering, Faculty of Science and Engineering & Henry Royce Institute, The University of Manchester, Manchester M13 9PL, UK.ORCID 0000-0002-6693-790X
Ana Colette MaurícioDepartamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal.ORCID 0000-0002-0018-9363

Funding

ANI 2022.10564.PTDCFundação para a Ciência e Tecnologia POCI-01-0145-FEDER-031146Fundação para a Ciência e Tecnologia SFRH/BD/146689/2019, 2021.05265.BD, 2023.00246.BD, 2023.00428.BD, 2023.00544.BDFundação para a Ciência e Tecnologia UIDB/00211/2020 , PEst-OE/AGR/UI0211/2011Henry Royce Institute EPSRC EP/R00661X/1, EP/S019367/1, EP/P025021/1 and EP/P025498/1
6 · The paper itself

Abstract

Three-dimensional (3D) models with improved biomimicry are essential to reduce animal experimentation and drive innovation in tissue engineering. In this study, we investigate the use of alginate-based materials as polymeric inks for 3D bioprinting of osteogenic models using human bone marrow stem/stromal cells (hBMSCs). A composite bioink incorporating alginate, nano-hydroxyapatite (nHA), type I collagen (Col) and hBMSCs was developed and for extrusion-based printing. Rheological tests performed on crosslinked hydrogels confirm the formation of solid-like structures, consistently indicating a superior storage modulus in relation to the loss modulus. The swelling behavior analysis showed that the addition of Col and nHA into an alginate matrix can enhance the swelling rate of the resulting composite hydrogels, which maximizes cell proliferation within the structure. The LIVE/DEAD assay outcomes demonstrate that the inclusion of nHA and Col did not detrimentally affect the viability of hBMSCs over seven days post-printing. PrestoBlue

Indexed as

alginatebioinkbioprintingbone regenerationcollagenhuman bone marrow stem/stromal cellshydroxyapatite

Identifiers

PMID39727588
PMCPMC11675550

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.