Evidence map›Paper›PMID 39727539›Full record

ArticleGels (Basel, Switzerland)2024

Physicochemical Properties, Drug Release and In Situ Depot-Forming Behaviors of Alginate Hydrogel Containing Poorly Water-Soluble Aripiprazole.

Hy D Nguyen, Munsik Jang, Hai V Ngo, Myung-Chul Gil, Gang Jin, Jing-Hao Cui, Qing-Ri Cao, Beom-Jin Lee

Abstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hy D NguyenDepartment of Pharmacy, College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea.ORCID 0000-0002-0951-1566
Munsik JangDepartment of Pharmacy, College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea.
Hai V NgoDepartment of Pharmacy, College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea.ORCID 0000-0002-5161-7911
Myung-Chul GilDepartment of Pharmacy, College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea.ORCID 0009-0005-8477-8120
Gang JinSchool of Chemical and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin 132022, China.
Jing-Hao CuiCollege of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
Qing-Ri CaoCollege of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
Beom-Jin LeeDepartment of Pharmacy, College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea.ORCID 0000-0003-0922-3289

Funding

Ministry of Science and ICT RS-2023-00208240
6 · The paper itself

Abstract

The objective of this study was to investigate the physicochemical properties, drug release and in situ depot-forming behavior of alginate hydrogel containing poorly water-soluble aripiprazole (ARP) for achieving free-flowing injectability, clinically accessible gelation time and sustained drug release. The balanced ratio of pyridoxal phosphate (PLP) and glucono-delta-lactone (GDL) was crucial to modulate gelation time of the alginate solution in the presence of calcium carbonate. Our results demonstrated that the sol state alginate hydrogel before gelation was free-flowing, stable and readily injectable using a small 23 G needle. In addition, the ratio (

Indexed as

alginate hydrogelcontrolled gelation timedrug release ratein situ depot-forming behaviorsphysicochemical propertiespoorly water-soluble aripiprazoleratio of pyridoxal phosphate and glucono-delta-lactone

Identifiers

PMID39727539
PMCPMC11675168

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.