Evidence map›Paper›PMID 39727531›Full record

ArticleGels (Basel, Switzerland)2024

Reinforcement of Dextran Methacrylate-Based Hydrogel, Semi-IPN, and IPN with Multivalent Crosslinkers.

Luca Paoletti, Gianluca Ferrigno, Nicole Zoratto, Daniela Secci, Chiara Di Meo, Pietro Matricardi

Abstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Luca PaolettiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0002-4252-7156
Gianluca FerrignoDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0002-6262-3217
Nicole ZorattoDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0002-4642-8227
Daniela SecciDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
Chiara Di MeoDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0002-3531-6107
Pietro MatricardiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0003-2086-911X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The need for new biomaterials to meet the needs of advanced healthcare therapies is constantly increasing. Polysaccharide-based matrices are considered extremely promising because of their biocompatibility and soft structure; however, their use is limited by their poor mechanical properties. In this light, a strategy for the reinforcement of dextran-based hydrogels and interpenetrated polymer networks (semi-IPNs and IPNs) is proposed, which will introduce multifunctional crosslinkers that can modify the network crosslinking density. Hydrogels were prepared via dextran methacrylation (DexMa), followed by UV photocrosslinking in the presence of diacrylate (NPGDA), triacrylate (TMPTA), and tetraacrylate (PETA) crosslinkers at different concentrations. The effect of these molecules was also tested on DexMa-gellan semi-IPN (DexMa/Ge) and, later, on IPN (DexMa/CaGe), obtained after solvent exchange with CaCl

Indexed as

crosslinkersdextran methacrylatehydrogelIPNstiffness

Identifiers

PMID39727531
PMCPMC11675718

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.