Evidence map›Paper›PMID 39727417›Full record

ArticlemBio2025

Inorganic polyphosphate and the stringent response coordinately control cell division and cell morphology in

Christopher W Hamm, Michael J Gray

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. The roles and synthesis of inorganic polyphosphate inbioRxiv : the preprint server for biology · 2026
    Article
  4. Polyphosphate synthesis is essential for phosphate and ATP homeostasis during nutrient upshift.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Christopher W HammDepartment of Microbiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Michael J GrayDepartment of Microbiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-7112-4188

Funding

Mentored Experiences in Research, Instruction and Teaching (MERIT) Program - administrative supplementK12GM088010 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHNEIDER, DAVID ALAN · 2009 to 2024
$9.2M
Molecular Mechanisms of Bacterial Stress Response Relevant to Host-Microbe InteractionsR35GM124590 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael Jeffrey Gray · 2017 to 2026
$3.5M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM124590NIGMS NIH HHS K12 GM088010NIGMS NIH HHS R35 GM124590
6 · The paper itself

Abstract

Bacteria encounter numerous stressors in their constantly changing environments and have evolved many methods to deal with stressors quickly and effectively. One well-known and broadly conserved stress response in bacteria is the stringent response, mediated by the alarmone (p)ppGpp. (p)ppGpp is produced in response to amino acid starvation and other nutrient limitations and stresses and regulates both the activity of proteins and expression of genes.

Indexed as

Cell DivisionEscherichia coliPolyphosphatesStress, PhysiologicalEscherichia coli ProteinsGene Expression Regulation, BacterialGuanosine PentaphosphateGuanosine TetraphosphateEscherichia coli ProteinsGuanosine PentaphosphateGuanosine TetraphosphatePolyphosphatescell divisioncell morphologypolyphosphate(p)ppGppstress responsestringent response

Identifiers

PMID39727417
PMCPMC11796413

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.