Evidence map›Paper›PMID 39727396›Full record

ArticleMicrobiology spectrum2025

Transendothelial migration of the Lyme disease spirochete involves spirochete internalization as an intermediate step through a transcellular pathway that involves Cdc42 and Rac1.

Daiana Alvarez-Olmedo, Claire Kamaliddin, Theodore B Verhey, May Ho, Rebekah De Vinney, George Chaconas

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Frontiers in immunology · 2026
    Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Daiana Alvarez-OlmedoDepartment of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada.
Claire KamaliddinDepartment of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada.
Theodore B VerheyDepartment of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada.
May HoCalvin, Phoebe & Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Rebekah De VinneyCalvin, Phoebe & Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
George ChaconasDepartment of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0002-9611-2095

Funding

The roles of Lyme spirochete adhesins in hematogenous disseminationR01AI169724 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI Jenifer L Coburn, JOHN M LEONG · 2022 to 2026
$3.6M
Canadian Government | Canadian Institutes of Health Research (CIHR) PJT-153336Canadian Government | Canadian Institutes of Health Research (CIHR) PJT-180584HHS | National Institutes of Health (NIH) R01AI18799NIAID NIH HHS R01 AI169724
6 · The paper itself

Abstract

Despite its importance in pathogenesis, the hematogenous dissemination pathway of

Indexed as

Borrelia burgdorfericdc42 GTP-Binding ProteinLyme Diseaserac1 GTP-Binding ProteinTransendothelial and Transepithelial MigrationCells, CulturedEndocytosisEndothelial CellsHumanscdc42 GTP-Binding ProteinCDC42 protein, humanrac1 GTP-Binding ProteinRAC1 protein, humanBorreliaborreliellaCdc42extravasationLyme borreliosisLyme diseaseRac1transendothelial migrationvascular transmigration

Identifiers

PMID39727396
PMCPMC11792520

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.