ArticleeLife2024
Learning enhances behaviorally relevant representations in apical dendrites.
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Apical integration theory provides a neural basis for understanding disorganization and consciousness in the schizophrenias.Current research in neurobiology · 2026Article
- Dopamine release-associated striatal blood oxygenation and whole-brain dynamics during associative learning.Science advances · 2026Article
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- Thalamocortical bursts encode reward contingencies and drive associative learning.Nature communications · 2026Article
- Region- and Layer-Specific Glutamatergic Synapse Development in the Nascent Cortical Hierarchy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Dissociating the Hallucinogenic and Neuroplastic Effects of Psilocybin.bioRxiv : the preprint server for biology · 2026Article
- Distinct sensorimotor encoding in tuft dendrites and somata associated with action, correction, and learning.bioRxiv : the preprint server for biology · 2026Article
- A shared predictive architecture in the sensory cortex for statistical and reward-based learning.Current opinion in neurobiology · 2026Review
- Perirhinal input to auditory cortex supports memory-guided sensory perception.Science advances · 2026Article
- Learning, prediction accuracy, and neural plasticity in sensory cortex.Current opinion in neurobiology · 2025Review
- Dendrites endow artificial neural networks with accurate, robust and parameter-efficient learning.Nature communications · 2025Article
- Article
- Article
- Dendrites endow artificial neural networks with accurate, robust and parameter-efficient learning.ArXiv · 2024Article
- Stability of cross-sensory input to primary somatosensory cortex across experience.bioRxiv : the preprint server for biology · 2024Article
- Review
- Audiovisualization of real-time neuroimaging data.PloS one · 2024Article
- Neuromuscular basis ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Neurophotonic tools for microscopic measurements and manipulation: status report.Neurophotonics · 2022Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
Learning alters cortical representations and improves perception. Apical tuft dendrites in cortical layer 1, which are unique in their connectivity and biophysical properties, may be a key site of learning-induced plasticity. We used both two-photon and SCAPE microscopy to longitudinally track tuft-wide calcium spikes in apical dendrites of layer 5 pyramidal neurons in barrel cortex as mice learned a tactile behavior. Mice were trained to discriminate two orthogonal directions of whisker stimulation. Reinforcement learning, but not repeated stimulus exposure, enhanced tuft selectivity for both directions equally, even though only one was associated with reward. Selective tufts emerged from initially unresponsive or low-selectivity populations. Animal movement and choice did not account for changes in stimulus selectivity. Enhanced selectivity persisted even after rewards were removed and animals ceased performing the task. We conclude that learning produces long-lasting realignment of apical dendrite tuft responses to behaviorally relevant dimensions of a task.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.