SynthesisWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Indications for the use of dermal substitutes in patients with acute burns and in reconstructive surgery after burns: A systematic review.
Synthesis in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effectiveness of negative-pressure wound therapy in partial-thickness and full-thickness burns: a systematic review.Acta cirurgica brasileira · 2026Pooled it
- Indications for the use of dermal substitutes in patients with acute burns and in reconstructive surgery after burns: A systematic review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyPooled it
- The Unknown Benefits of Dermal Matrices in Prevent Loss of Albumin in Patient with Major Burns.European burn journal · 2026Article
- Photothermal interaction of a 1927 nm Thulium laser with MatriDerm: an in vitro study.Lasers in medical science · 2026Article
- Defining dermal matrices: Results of a global Delphi panel in surgical reconstruction.JPRAS open · 2026Article
- RNA Coding and Transcriptional Regulation in Skin Repair: Insights from Single-Cell Profiling and Implications for Organoid-Based Regenerative Strategies.Life (Basel, Switzerland) · 2026Review
- Short-term pretreatment with deferoxamine enhances the in vivo vascularization capacity of nanofat seeded onto dermal substitutes.EXCLI journal · 2026Article
- Safety and efficacy of bio-engineered, autologous dermo-epidermal skin grafts in adolescent and adult burn patients: 1-year results of a prospective, randomized, controlled, multicenter phase IIB clinical trial.EClinicalMedicine · 2025Article
- [Efficacy of artificial dermis in repairing small to medium-sized deep partial-thickness scalds in infants and young children].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025Observational
- Review
- The Role of Skin Substitutes in the Therapeutical Management of Burns Affecting Functional Areas.Medicina (Kaunas, Lithuania) · 2025Review
- Safety and efficacy of bio-engineered, autologous dermo-epidermal skin grafts in reconstructive surgery: 1-year results of a prospective, randomized, intra-patient controlled, multicenter phase II clinical trial.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Deep dermal and full-thickness burns often result in scar sequelae such as contractures, hypertrophy, pain and itching following split-thickness skin grafting. Dermal substitutes are currently employed alongside split-thickness skin grafting to enhance clinical outcomes, though their indications remain a subject of ongoing debate. This systematic review aims to clarify the indications for the application of dermal substitutes in burn patients, in both acute and reconstructive settings. A comprehensive search across various databases was conducted. Studies (n = 190) assessing the indications and outcomes of dermal substitutes in acute burn patients and those requiring reconstructive surgery were included. Data extraction included the applied dermal substitute, age, total body surface area, wound depth, burn aetiology, anatomical site and exclusion criteria. The indications were derived from predetermined indications, i.e. inclusion and exclusion criteria and patient characteristics. The depth of the wound emerged as the primary indication for dermal substitute use. A one-stage approach is recommended for deep dermal to full-thickness wounds larger than 10 cm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.