Evidence map›Paper›PMID 39726967›Full record

ReviewFrontiers in microbiology2024

Genome mining and biosynthetic pathways of marine-derived fungal bioactive natural products.

Caihua Han, Anjing Song, Yueying He, Liu Yang, Litong Chen, Wei Dai, Qilin Wu, Siwen Yuan

Abstract readReview
In one paragraph

Review in Frontiers in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Marine natural products.Natural product reports · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Caihua HanSchool of Bioengineering, Zunyi Medical University, Zhuhai, China.
Anjing SongSchool of Bioengineering, Zunyi Medical University, Zhuhai, China.
Yueying HeSchool of Bioengineering, Zunyi Medical University, Zhuhai, China.
Liu YangSchool of Bioengineering, Zunyi Medical University, Zhuhai, China.
Litong ChenCenter of Ocean Expedition, School of Atmospheric Science, Sun Yat-sen University, Zhuhai, China.
Wei DaiTeaching and Experimental Center, Guangdong Pharmaceutical University, Guangzhou, China.
Qilin WuSchool of Bioengineering, Zunyi Medical University, Zhuhai, China.
Siwen YuanSchool of Bioengineering, Zunyi Medical University, Zhuhai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Marine fungal natural products (MFNPs) are a vital source of pharmaceuticals, primarily synthesized by relevant biosynthetic gene clusters (BGCs). However, many of these BGCs remain silent under standard laboratory culture conditions, delaying the development of novel drugs from MFNPs to some extent. This review highlights recent efforts in genome mining and biosynthetic pathways of bioactive natural products from marine fungi, focusing on methods such as bioinformatics analysis, gene knockout, and heterologous expression to identify relevant BGCs and elucidate the biosynthetic pathways and enzyme functions of MFNPs. The research efforts presented in this review provide essential insights for future gene-guided mining and biosynthetic pathway analysis in MFNPs.

Indexed as

biosynthesisbiosynthetic gene clustersgenome miningmarine fungimarine natural products

Identifiers

PMID39726967
PMCPMC11669671

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.