Evidence map›Paper›PMID 39726939›Full record

ArticleAutophagy reports2024

Autophagy deficiency protects against ocular hypertension and glaucoma.

Angela Dixon, Myoung Sup Shim, April Nettesheim, Aislyn Coyne, Chien-Chia Su, Haiyan Gong, Paloma B Liton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Angela DixonDepartment of Ophthalmology & Pathology, Duke University, Durham, NC, 27705, USA.
Myoung Sup ShimDepartment of Ophthalmology & Pathology, Duke University, Durham, NC, 27705, USA.
April NettesheimDepartment of Ophthalmology & Pathology, Duke University, Durham, NC, 27705, USA.
Aislyn CoyneDepartment of Ophthalmology & Pathology, Duke University, Durham, NC, 27705, USA.
Chien-Chia SuDepartment of Ophthalmology & Pathology, Duke University, Durham, NC, 27705, USA.
Haiyan GongDepartment of Ophthalmology, Boston University School of Medicine, Boston, MA, 02118, USA.
Paloma B LitonDepartment of Ophthalmology & Pathology, Duke University, Durham, NC, 27705, USA.ORCID 0000-0002-1440-3762

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Goldis Malek · 1985 to 2026
$19.3M
Autophagy and Mechanotransduction in the Trabecular MeshworkR01EY026885 · NEI · DUKE UNIVERSITY · PI Paloma Liton · 2016 to 2026
$4.7M
Autophagy and Retinal Ganglion Cell Death in GlaucomaR01EY033600 · NEI · DUKE UNIVERSITY · PI LITON, PALOMA · 2022 to 2025
$1.9M
NEI NIH HHS P30 EY005722NEI NIH HHS R01 EY026885NEI NIH HHS R01 EY033600
6 · The paper itself

Abstract

Glaucoma encompasses a spectrum of disorders characterized by the chronic degeneration of retinal ganglion cell (RGC) axons and the progressive loss of RGCs, resulting in visual impairment. In this study, we investigated the effect of autophagy deficiency on two glaucoma hypertensive models, the DBA/2J spontaneous glaucoma model, and the TGFβ2 (transforming growth factor β2) chronic ocular hypertensive model. For this, we used the

Indexed as

AutophagyDBA/2Jglaucomaocular hypertensionoptic nerveRGC

Identifiers

PMID39726939
PMCPMC11671156

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.