Evidence map›Paper›PMID 39726934›Full record

ReviewWorld journal of clinical cases2024

Oral blood pressure augmenting agents for intravenous vasopressor weaning.

John C Robinson, Mariam ElSaban, Nathan J Smischney, Patrick M Wieruszewski

Abstract readReview
In one paragraph

Review in World journal of clinical cases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Pseudoephedrine for Central Sympathetic Insufficiency.Journal of clinical neurology (Seoul, Korea) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

John C RobinsonDepartment of Pharmacy, Mayo Clinic, Phoenix, AZ 85054, United States.
Mariam ElSabanDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN 55905, United States.
Nathan J SmischneyDepartment of Anesthesiology, Mayo Clinic, Rochester, MN 55905, United States.
Patrick M WieruszewskiDepartment of Anesthesiology, Mayo Clinic, Rochester, MN 55905, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intravenous (IV) vasopressors are essential in the management of hypotension and shock. Initiation of oral vasoactive agents to facilitate weaning of IV vasopressors to liberate patients from the intensive care unit is common despite conflicting evidence regarding the benefits of this practice. While midodrine appears to be the most frequently studied oral vasoactive agent for this purpose, its adverse effect profile may preclude its use in certain populations. In addition, some patients may require persistent use of IV vasopressors for hypotension refractory to midodrine. The use of additional and alternative oral vasoactive agents bearing different mechanisms of action is emerging. This article provides a comprehensive review of the pharmacology, clinical uses, dosing strategies, and safety considerations of oral vasoactive agents and their application in the intensive care setting.

Indexed as

AtomoxetineDroxidopaHypotensionMidodrinePseudoephedrineShockVasopressor

Identifiers

PMID39726934
PMCPMC11531983

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.