Evidence map›Paper›PMID 39726853›Full record

ArticlePain reports2025

Applying evidence-based cross-disciplinary concepts helps to explain the heterogeneity in pain, function, and biological measures in individuals with knee pain with/at risk of osteoarthritis.

Angela M Mickle, Jared J Tanner, Udell Holmes, Ahmed Rashid, Olivier Barolette, Brittany Addison, Nicola Sambuco, Cynthia Garvan, Song Lai, Christoph Seubert and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Angela M MickleDepartment of Physical Medicine & Rehabilitation, College of Medicine, University of Florida, Gainesville, FL, USA.ORCID https://orcid.org/0000-0001-9175-5342
Jared J TannerDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Udell HolmesDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Ahmed RashidDepartment of Physical Medicine & Rehabilitation, College of Medicine, University of Florida, Gainesville, FL, USA.
Olivier BaroletteDepartment of Physical Medicine & Rehabilitation, College of Medicine, University of Florida, Gainesville, FL, USA.
Brittany AddisonDepartment of Physical Medicine & Rehabilitation, College of Medicine, University of Florida, Gainesville, FL, USA.
Nicola SambucoDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Cynthia GarvanDepartment of Anesthesiology, Division of Pain Medicine, University of Florida, Gainesville, FL, USA.
Song LaiDepartment of Radiation Oncology & CTSI Human Imaging Core, University of Florida, Gainesville, FL, USA.
Christoph SeubertDepartment of Anesthesiology, Division of Pain Medicine, University of Florida, Gainesville, FL, USA.
Siegfried SchmidtDepartment of Community Health and Family Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Roland StaudDepartment of Rheumatology, College of Medicine, University of Florida, Gainesville, FL, USA.
Jeffrey C EdbergDepartment of Medicine, Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
David ReddenDepartment of Biostatistics, The University of Alabama at Birmingham, Birmingham, AL, USA.
Burel R GoodinDepartment of Anesthesia, Washington University, St. Louis, MO, USA.
Catherine C PriceDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Roger B FillingimPain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, USA.
Kimberly T SibilleDepartment of Physical Medicine & Rehabilitation, College of Medicine, University of Florida, Gainesville, FL, USA.

Funding

Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2000 to 2026
$31.9M
NIDDK NIH HHS P30 DK056336
6 · The paper itself

Abstract

Introduction: Factors contributing to individual differences in knee osteoarthritis remain elusive. Dispositional traits and socioeconomic status are independent predictors of mental and physical health, although significant variability remains. Dispositional traits serve as the biological interface for life experiences. Objectives: We investigate group differences based on dispositional traits and poverty status, specific to (1) pain intensity and functional limitations and (2) biological measures, a clinical composite and brain age. Methods: Adults aged 45 to 85 years with knee pain associated with chronic musculoskeletal pain provided information on demographics, socioeconomic and psychosocial factors, pain, and physical function. Kellgren-Lawrence scores were determined from knee radiographs, the clinical composite from fasting blood draws, and brain age from MRI data. Results: One hundred seventy-three individuals participated in the study. Of those, 117 had protective dispositional traits (81 above poverty/36 in poverty), and 56 had vulnerable dispositional traits (24 above poverty/32 in poverty). With sex, study site, Kellgren-Lawrence score, and age/or image quality as covariates, significant group differences were observed across clinical pain ( Conclusions: Groups based on dispositional traits and socioeconomic status explain differing clinical outcomes. Consistent with the allostatic load and hormesis inverted U models, one group was in an adaptive health status, 2 groups were showing signs of developing load, and the fourth group showing signs of overload, at risk of worse health outcomes.

Indexed as

Brain ageChronic painDispositional traitsFinancial stressKnee osteoarthritis

Identifiers

PMID39726853
PMCPMC11671054

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.