Evidence map›Paper›PMID 39726789›Full record

ArticleFrontiers in pharmacology2024

Influence of inhaled nitric oxide on bronchopulmonary dysplasia in preterm infants with PPHN or HRF at birth: a propensity score matched study.

Xue-Rong Huang, Lian Wang, Guo-Bao Liang, Sheng-Qian Huang, Bao-Ying Feng, Lu Zhu, Xu-Fang Fan, Mu-Lin Yao, Jing Zhang, Meng-Jiao Wang and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Xue-Rong Huang *Department of Neonatology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Lian Wang *Department of Neonatology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Guo-Bao Liang *Department of Neonatology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Sheng-Qian Huang *Department of Neonatology, Guiyang Maternal and Child Healthcare Hospital, Guiyang Children's Hospital, Guiyang, Guizhou, China.
Bao-Ying Feng *Department of Neonatology, Maternal and Child Health Hospital of the Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.
Lu Zhu *Department of Neonatology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Xu-Fang Fan *Department of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Mu-Lin Yao *Department of Neonatology, Children's Hospital of Hebei province, Shijiazhuang, Hebei, China.
Jing Zhang *Department of Neonatology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Meng-Jiao Wang *Department of Neonatology, Northwest Women's and Children's Hospital, Xi'an, Shanxi, China.
Zhi ZhengDepartment of Neonatology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Yao ZhuDepartment of Neonatology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Wen-Li DuanDepartment of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Zhan-Kui LiDepartment of Neonatology, Northwest Women's and Children's Hospital, Xi'an, Shanxi, China.
Jian MaoDepartment of Neonatology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Li MaDepartment of Neonatology, Children's Hospital of Hebei province, Shijiazhuang, Hebei, China.
Fa-Lin XuDepartment of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Fan WuDepartment of Neonatology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Qiu-Fen WeiDepartment of Neonatology, Maternal and Child Health Hospital of the Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.
Ling LiuDepartment of Neonatology, Guiyang Maternal and Child Healthcare Hospital, Guiyang Children's Hospital, Guiyang, Guizhou, China.
Xin-Zhu LinDepartment of Neonatology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bronchopulmonary Dysplasia (BPD) is a chronic lung disease affecting preterm infants, with limited prevention and treatment options. Inhaled Nitric Oxide (iNO) is sometimes used to treat Persistent Pulmonary Hypertension of the Newborn (PPHN) and Hypoxemic Respiratory Failure (HRF), and its impact on BPD development remains debated. Objective: To assess whether iNO-related factors are potential contributors to the development of BPD Grade Ⅱ-Ⅲ in very premature infants (VPI) diagnosed with PPHN or HRF at birth using Propensity Score Matching (PSM). Methods: We conducted a retrospective cohort study of infants born at 22-32 weeks gestation with PPHN or HRF, treated with iNO for over 3 h. PSM matched groups by gestational age, birth weight, and gender, etc. Multivariate logistic regression evaluated the association between iNO treatment and BPD outcomes to identify influencing factors, while Restricted Cubic Spline (RCS) and mediation analysis examined iNO dose effects and potential mediators like mechanical ventilation time and oxygenation index (OI). Results: A higher initial iNO dose was significantly associated with a reduced risk of BPD Grade Ⅱ-Ⅲ ( Conclusion: A higher initial iNO dose within the first 7 days was associated with a reduced risk of BPD Grade Ⅱ-Ⅲ in VPI with PPHN or HRF.

Indexed as

BPD (bronchopulmonary dysplasia)hypoxemic respiratory failurenitric oxide - NOPPHN (persistent pulmonary hypertension of the newborn)very premature infant

Identifiers

PMID39726789
PMCPMC11670073

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.