Evidence map›Paper›PMID 39726771›Full record

ArticleFrontiers in behavioral neuroscience2024

Shifts in naturalistic behaviors induced by early social isolation stress are associated with adult binge-like eating in female rats.

Timothy B Simon, Julio Sierra, Arianna Williams, Giara Wright, Allison Rhee, Julius Horn, John Lou, Fransua Sharafeddin, Perla Ontiveros-Ángel, Johnny D Figueroa

Abstract read
In one paragraph

Article in Frontiers in behavioral neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Timothy B SimonCenter for Health Disparities and Molecular Medicine, Department of Basic Sciences, Loma Linda University Health School of Medicine, Loma Linda, CA, United States.
Julio SierraCenter for Health Disparities and Molecular Medicine, Department of Basic Sciences, Loma Linda University Health School of Medicine, Loma Linda, CA, United States.
Arianna WilliamsCenter for Health Disparities and Molecular Medicine, Department of Basic Sciences, Loma Linda University Health School of Medicine, Loma Linda, CA, United States.
Giara WrightCenter for Health Disparities and Molecular Medicine, Department of Basic Sciences, Loma Linda University Health School of Medicine, Loma Linda, CA, United States.
Allison RheeCenter for Health Disparities and Molecular Medicine, Department of Basic Sciences, Loma Linda University Health School of Medicine, Loma Linda, CA, United States.
Julius HornCenter for Health Disparities and Molecular Medicine, Department of Basic Sciences, Loma Linda University Health School of Medicine, Loma Linda, CA, United States.
John LouLoma Linda University School of Behavioral Health, Loma Linda, CA, United States.
Fransua SharafeddinCenter for Health Disparities and Molecular Medicine, Department of Basic Sciences, Loma Linda University Health School of Medicine, Loma Linda, CA, United States.
Perla Ontiveros-ÁngelCenter for Health Disparities and Molecular Medicine, Department of Basic Sciences, Loma Linda University Health School of Medicine, Loma Linda, CA, United States.
Johnny D FigueroaCenter for Health Disparities and Molecular Medicine, Department of Basic Sciences, Loma Linda University Health School of Medicine, Loma Linda, CA, United States.

Funding

NIH-LLU Initiative for Maximizing Student DiversityR25GM060507 · NIGMS · LOMA LINDA UNIVERSITY · PI DE LEON, MARINO · 2001 to 2022
$11.3M
Research Training/Education CoreP20MD006988 · NIMHD · LOMA LINDA UNIVERSITY · PI DE LEON, MARINO · 2012 to 2016
$6.2M
NEUROPATHOLOGICAL SIGNATURES CONNECTING EARLY-LIFE TRAUMA TO COMPULSIVE EATING BEHAVIOR AND OBESITYR21DK124727 · NIDDK · LOMA LINDA UNIVERSITY · PI FIGUEROA, JOHNNY DAVIS · 2020 to 2022
$753k
NIDDK NIH HHS R21 DK124727NIGMS NIH HHS R25 GM060507NIMHD NIH HHS P20 MD006988
6 · The paper itself

Abstract

Binge eating (BE) is a highly pervasive maladaptive coping strategy in response to severe early life stress such as emotional and social neglect. BE is described as repeated episodes of uncontrolled eating and is tightly linked with comorbid mental health concerns. Despite social stressors occurring at a young age, the onset of BE typically does not occur until adulthood providing an interval for potential therapeutic intervention. Currently, our knowledge of longitudinal noninvasive digital biomarkers predictive of BE needs further development. Monitoring longitudinal impacts of adolescent social isolation stress on naturalistic behaviors in rats will enable the identification of noninvasive digital markers of disease progression to predict adult eating strategies. Recognizing adolescent naturalistic behaviors shaped by social stress informs our understanding of the underlying neurocircuits most effected. This study aimed to monitor and identify longitudinal behavioral shifts to enhance predictive capabilities in a rat model of social isolation stress-induced BE. We placed Paired (

Indexed as

binge eatingearly life adversityfemale rodentslongitudinalnaturalistic behaviorobservational cagesphenotypingsocial isolation stress

Identifiers

PMID39726771
PMCPMC11669510

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.