Evidence map›Paper›PMID 39726280›Full record

ArticleCancer science2025

TIM-3 marks measurable residual leukemic stem cells responsible for relapse after allogeneic stem cell transplantation.

Teppei Sakoda, Yoshikane Kikushige, Hidetoshi Irifune, Gentaro Kawano, Takuya Harada, Yuichiro Semba, Masayasu Hayashi, Takahiro Shima, Yasuo Mori, Tetsuya Eto and 8 more

Abstract read
In one paragraph

Article in Cancer science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. TIM-3 in AML: pathogenic roles and therapeutic targetability.Clinical and experimental medicine · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Teppei SakodaDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, Fukuoka, Japan.ORCID https://orcid.org/0000-0002-7521-0366
Yoshikane KikushigeDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, Fukuoka, Japan.ORCID https://orcid.org/0000-0002-7721-1696
Hidetoshi IrifuneDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, Fukuoka, Japan.ORCID https://orcid.org/0000-0001-9354-4661
Gentaro KawanoDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Takuya HaradaDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Yuichiro SembaDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Masayasu HayashiDepartment of Hematology, Hamanomachi Hospital, Fukuoka, Japan.
Takahiro ShimaDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Yasuo MoriDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Tetsuya EtoDepartment of Hematology, Hamanomachi Hospital, Fukuoka, Japan.
Tomohiko KamimuraDepartment of Hematology, Harasanshin Hospital, Fukuoka, Japan.
Hiromi IwasakiDepartment of Hematology, National Hospital Organisation Kyushu Medical Center, Fukuoka, Japan.
Ryosuke OgawaDepartment of Hematology/Oncology, Japan Community Health Care Organisation Kyushu Hospital, Kitakyushu, Japan.
Goichi YoshimotoDepartment of Hematology, Saga Prefecture Medical Center Koseikan, Saga, Japan.
Koji KatoDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Takahiro MaedaDivision of Precision Medicine, Kyushu University Faculty of Medicine Graduate School of Medical Science, Fukuoka, Japan.
Toshihiro MiyamotoDepartment of Hematology, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Koichi AkashiDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, Fukuoka, Japan.

Funding

Chugai foundation for Innovative Drug Discovery ScienceFukuoka Public Health Promotion Organization Cancer Research FundJapanese Society of HematologyJapan Society for the Promotion of Science Grant-in-Aid for Scientific Research (A) 21407314Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research (B) 21385681Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research (B) 22494899KaketsukenMEXT Promotion of Development of a Joint Usage / Research System Project: Coalition of Universities for Research Excellence Program (CURE) JPMXP1323015484NOVARTIS Foundation (Japan) for the Promotion of SciencePrincess Takamatsu Cancer Research FundSENSHIN Medical Research FoundationShinnihon Foundation of Advanced Medical Treatment ResearchTakeda Medical Research FoundationUehara Memorial Foundation
6 · The paper itself

Abstract

In this study, we investigated the measurable residual leukemic stem cell (MR-LSC) population after allogeneic stem cell transplantation (allo-SCT) for high-risk acute myeloid leukemia (AML), utilizing T-cell immunoglobulin mucin-3 (TIM-3) expression as a functional marker of AML leukemic stem cells (LSCs). Analysis of the CD34

Indexed as

Hematopoietic Stem Cell TransplantationHepatitis A Virus Cellular Receptor 2Leukemia, Myeloid, AcuteNeoplastic Stem CellsAdolescentAdultAgedDisease-Free SurvivalFemaleHumansMaleMiddle AgedMutationNeoplasm, ResidualRecurrenceTransplantation, HomologousHAVCR2 protein, humanHepatitis A Virus Cellular Receptor 2acute myeloid leukemiaallogeneic stem cell transplantationleukemic stem cellsmeasurable residual diseaseTIM‐3

Identifiers

PMID39726280
PMCPMC11875787

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.