Evidence map›Paper›PMID 39726003›Full record

ArticleDiagnostic pathology2024

Aberrant bcl6 protein expression in patients with EMZL following recurrence or progression: case report of two cases.

Ming Zhang, Jianli Qu, Weiwei Guo, Yi Liu, Wei Zhang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostic pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Ming ZhangDepartment of Pathology, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, 264003, Shandong, China.
Jianli QuDepartment of Pathology, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, 264003, Shandong, China.
Weiwei GuoDepartment of Pathology, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, 264003, Shandong, China.
Yi LiuDepartment of Hematology, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, 264003, Shandong, China.
Wei ZhangDepartment of Pathology, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, 264003, Shandong, China. 15165736627@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (EMZL) is an indolent B-cell lymphoma that can involve various anatomic sites. EMZL is derived from post-germinal center marginal zone B cells and typically lacks bcl-6 expression. Herein, we report two post-treatment cases of EMZL where unexpected bcl-6 protein expression was observed in specimens obtained following recurrence or progression. This contrasts with the primary specimens, which were negative for the bcl-6. Additionally, we confirm that the altered bcl6 expression observed in relapsed EMZL cases is independent of BCL6 gene rearrangement, as demonstrated by fluorescence in situ hybridization analysis. Relevant literature was reviewed and summarized to enhance the understanding of this phenomenon, particularly for pathologists.

Indexed as

Disease ProgressionLymphoma, B-Cell, Marginal ZoneProto-Oncogene Proteins c-bcl-6AgedBiomarkers, TumorFemaleHumansImmunohistochemistryIn Situ Hybridization, FluorescenceMaleMiddle AgedNeoplasm Recurrence, LocalBCL6 protein, humanBiomarkers, TumorProto-Oncogene Proteins c-bcl-6BCL6 gene rearrangementBcl6 protein expressionExtranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (EMZL, MALT lymphoma)High-grade transformation (HT)

Identifiers

PMID39726003
PMCPMC11670503

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.