Evidence map›Paper›PMID 39725999›Full record

ArticleJournal of neuroinflammation2024

CCR2 restricts IFN-γ production by hippocampal CD8 TRM cells that impair learning and memory during recovery from WNV encephalitis.

Shenjian Ai, Artem Arutyunov, Joshua Liu, Jeremy D Hill, Xiaoping Jiang, Robyn S Klein

Abstract read
In one paragraph

Article in Journal of neuroinflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. The neuroimmune system and cognition.Nature immunology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Shenjian AiCenter for Neuroimmunology and Neuroinfectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.
Artem ArutyunovCenter for Neuroimmunology and Neuroinfectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.
Joshua LiuDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Jeremy D HillCenter for Neuroimmunology and Neuroinfectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.
Xiaoping JiangCenter for Neuroimmunology and Neuroinfectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.
Robyn S KleinDepartment of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. rklein8@uwo.ca.

Funding

Research Program Award (R35 Clinical Trial Optional) - Dr. Robyn Klein NINDSR35NS122310 · NINDS · WASHINGTON UNIVERSITY · PI CAIN, MATTHEW D · 2021 to 2024
$3.7M
Canada Excellence Research Chairs, Government of Canada CERC-2022-00107NINDS NIH HHS R35 NS122310NINDS NIH HHS R35NS122310
6 · The paper itself

Abstract

Central nervous system (CNS) resident memory CD8 T cells (T

Indexed as

CD8-Positive T-LymphocytesHippocampusInterferon-gammaMice, Inbred C57BLReceptors, CCR2West Nile FeverAnimalsMemory DisordersMiceMice, KnockoutWest Nile virusCcr2 protein, mouseInterferon-gammaReceptors, CCR2

Identifiers

PMID39725999
PMCPMC11673327

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.