Evidence map›Paper›PMID 39725947›Full record

ArticleBMC oral health2024

Fibula flap reconstruction for maxillary stage 3 medication-related osteonecrosis of the jaw from recipient and donor site perspectives: a preliminary single-center study.

Yuhan Lin, Jin Wang, Yongzhen Lai, Chuanqing Mao, Meng Lu, Chengyong Wang, Qiming Ouyang, Yue He, Weihui Chen

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuhan Lin *Department of Oral and Maxillofacial Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Jin Wang *Department of Oral and Maxillofacial Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Yongzhen LaiDepartment of Oral and Maxillofacial Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Chuanqing MaoDepartment of Oral and Maxillofacial Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Meng LuDepartment of Oral and Maxillofacial Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Chengyong WangDepartment of Oral and Maxillofacial Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Qiming OuyangDepartment of Oral and Maxillofacial Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Yue HeDepartment of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, China. william5218@126.com.
Weihui ChenDepartment of Oral and Maxillofacial Surgery, Fujian Medical University Union Hospital, Fuzhou, China. whchen@fjmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhile the surgical treatment of mandibular stage 3 medication-related osteonecrosis of the jaw (MRONJ) is well-documented, research on maxillary stage 3 MRONJ is limited. Antiresorptive medications can induce MRONJ and atypical femoral fracture (AFF), but their impact on the feasibility of using fibula flaps for reconstruction remains controversial. This study aimed to assess the surgical outcomes and functional recovery of fibula flap reconstruction for maxillary stage 3 MRONJ, considering both recipient and donor site outcomes.

methodsThis retrospective study included patients with maxillary stage 3 MRONJ who underwent fibula flap reconstruction. Demographic and clinical features, postoperative complications, long-term outcomes and functional recovery of both recipient and donor sites were analyzed. Long-term outcomes included the survival of fibula flaps, the incidence of fibula graft or tibia fractures, recurrence of MRONJ, and patient survival status. Function assessments focused on speech, swallowing, and ankle joint.

resultsSeven patients (two with multiple myeloma, five with bone metastases) were included. Two patients experienced delayed healing at the donor site, both of whom recovered within two months postoperatively. All fibula flaps survived with primary healing. There were no recurrences of MRONJ or fractures of fibula graft or tibia. The mean speech function score was 28.00 ± 12.03, the mean swallowing function score was 2.86 ± 2.79, the mean pain score of donor site was 2.71 ± 2.29, and the mean ankle function score was 94.43 ± 4.35.

conclusionFibula flap reconstruction is feasible for maxillary stage 3 MRONJ, yielding satisfactory surgical outcomes and functional recovery.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawFibulaAgedAged, 80 and overBone TransplantationFemaleHumansMaleMaxillary DiseasesMiddle AgedPlastic Surgery ProceduresRetrospective StudiesSurgical FlapsTransplant Donor SiteTreatment OutcomeDonor siteFibula flapMaxillaMedication-related osteonecrosis of the jawRecipient site

Identifiers

PMID39725947
PMCPMC11674523

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.