ArticleBMC neuroscience2024
Structural-functional connectivity decoupling in multiscale brain networks in Parkinson's disease.
Article in BMC neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Altered static and dynamic functional network connectivity in Parkinson's disease: A multisite functional magnetic resonance imaging study.IBRO neuroscience reports · 2026Article
- Investigation of cerebellar structure and static and dynamic functional connectivity in cervical spondylotic myelopathy patients.Neuroradiology · 2026Article
- Decreased amyloid-related structure-function coupling in preclinical Alzheimer's disease.Communications medicine · 2026Article
- Iron accumulation in the substantia nigra is linked to functional network connectivity alterations in early-stage Parkinson's Disease: an exploratory study.NPJ Parkinson's disease · 2026Article
- Diffusion tensor imaging-functional MRI fusion reveals disrupted white matter structure-function coupling in HIV-associated asymptomatic neurocognitive impairment.Frontiers in neuroscience · 2026Article
- Multiscale parcellation of dynamic causal models of the brain.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundParkinson's disease (PD) is a progressive neurodegenerative disease associated with functional and structural alterations beyond the nigrostriatal dopamine projection. However, the structural-functional (SC-FC) coupling changes in combination with subcortical regions at the network level are rarely investigated in PD.
methodsSC-FC coupling networks were systematically constructed using the structural connectivity obtained by diffusion tensor imaging and the functional connectivity obtained by resting-state functional magnetic resonance imaging in 53 PD and 72 age- and sex-matched healthy controls (HCs). Then, we explored how SC-FC coupling varied within and between several well-defined functional domains.
resultsResults showed that the SC-FC coupling in patients with PD was globally reduced in comparison with HCs. Specifically, regional SC-FC decoupled in the inferior parietal lobule, occipitotemporal cortex, motor cortex, and higher-order association cortex in patients with PD. Moreover, PD showed intranetwork SC-FC decoupling in the visual network (VIS), limbic and higher-order association networks. Furthermore, internetwork decoupling mainly linked to the VIS, the somatomotor network (SOM), the dorsal attention network, and the default mode network, was observed, increased internetwork coupling was found between the subcortical network and the SOM in PD (all p < 0.05, FDR corrected).
conclusionsThese findings suggest that PD is characterized by SC-FC decoupling in topological organization of multiscale brain networks, providing insights into the brain network mechanisms in PD.
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