ArticleAging clinical and experimental research2024
Impacts of osteosarcopenia on musculoskeletal health, risks of falls and fractures, and activities of daily living among population aged 50 and above: an age- and sex-matched cross-sectional analysis.
Article in Aging clinical and experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The Efficacy of Piascledine in Alleviating Symptoms and Its Impact on Blood Lipid Levels and body Mass Index in Patients with Knee Osteoarthritis.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2024Trial
- Observational
- AI-driven appendicular skeletal muscle mass index (ASMI) prediction and low muscle mass detection from routine hip X-rays: a novel opportunistic case finding tool.European geriatric medicine · 2026Article
- The Rising Burden of Osteosarcopenia in Older Adults: A Narrative Review of Pathophysiology, Diagnostic Challenges, and Therapeutic Perspectives.Health science reports · 2026Article
- Is P TO P (Pedicle-To-Pedicle) technique superior to bilateral percutaneous vertebral augmentation for thoracic and lumbar osteoporotic vertebral compression fracture? Evidence from a retrospective study.BMC musculoskeletal disorders · 2026Article
- Article
- Quality of life trajectories following geriatric hip fracture surgery: a growth mixture modelling approach.Journal of orthopaedic surgery and research · 2026Article
- Interorgan Communications in Skeletal Pathophysiology: From Molecular Pathways to Multidisciplinary Therapies.Research (Washington, D.C.) · 2026Review
- Osteosarcopenia as a predictor of postoperative adverse outcomes in older adults undergoing total hip arthroplasty.Journal of bone and mineral metabolism · 2026Article
- Longitudinal trajectories of walking speed and risk of incident hip fracture in osteoporosis: a group-based trajectory modeling analysis from HRS, ELSA and SHARE.Frontiers in public health · 2026Article
- LncRNA NR2F1-AS1 is involved in osteogenic differentiation in fracture healing via miR-423-5p.Cytotechnology · 2025Article
- Association of spinopelvic mobility and osteosarcopenia with total hip arthroplasty outcomes.Journal of experimental orthopaedics · 2025Article
- Influence of helicobacter pylori infection on Chinese adult males' body muscle mass: a cross-sectional and cohort analysis.Frontiers in cellular and infection microbiology · 2025Article
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7 authors.
Funding
Abstract
aimsWe conducted this study to investigate the impact of muscle loss on musculoskeletal health, fall and fracture risks, and activities of daily living (ADL) in elderly patients with osteoporosis. MATERIALS AND
methodsThis age- and sex-matched cross-sectional study analyzed data from a medical center involving patients aged ≥ 50 from 2020 to 2022. The included participants were formed into three groups: 100 with osteoporosis only, 100 with osteosarcopenia, and 50 control individuals without osteoporosis and sarcopenia. We compared groups based on their baseline characteristics, bone and muscle health measurements, and the risks of falls and fractures using the STRATIFY scale and FRAX, respectively. Additionally, ADL was assessed using the Barthel Index. A multivariate analysis was performed to identify factors associated with declined ADL in osteosarcopenic patients.
resultsThe mean age was 76.17 years, and 82% were female. The osteosarcopenic group demonstrated poorer bone and muscle quality and quantity, with greater risks of major osteoporotic-related fractures, hip fractures, and falls, as well as significantly decreased ADL than other groups. When comparing sexes, females exhibited worse performance than males across groups. Slow gait speed and high STRATIFY score are independent predictors of declined ADL in osteosarcopenic patients.
conclusionSarcopenia exacerbates osteoporotic patients, particularly women, worsening bone deterioration, increasing fall and fracture risks, and significantly impairing daily activities. Enhancing walking speed and reducing fall risk can boost independence in individuals with osteosarcopenia. Early detection, proper management, and preventive measures are essential for mitigating these adverse outcomes in high-risk individuals.
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