Evidence map›Paper›PMID 39725808›Full record

ArticleCellular and molecular life sciences : CMLS2024

Characterisation and hierarchy of the spermatogonial stem cell compartment in human spermatogenesis by spectral cytometry using a 16-colors panel.

C Lapoujade, M Blanco, M Givelet, A S Gille, I Allemand, L Lenez, N Thiounn, S Roux, J P Wolf, C Patrat and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

C LapoujadeUniversité Paris-Saclay, CEA, UMR Stabilité Génétique Cellules Souches Et Radiations, iRCM/IBFJ, Laboratoire Des Cellules Souches Germinales, 92265, Fontenay-Aux-Roses, France.
M BlancoUniversité Paris-Saclay, CEA, UMR Stabilité Génétique Cellules Souches Et Radiations, iRCM/IBFJ, Laboratoire Des Cellules Souches Germinales, 92265, Fontenay-Aux-Roses, France.
M GiveletUniversité Paris-Saclay, CEA, UMR Stabilité Génétique Cellules Souches Et Radiations, iRCM/IBFJ, Laboratoire Des Cellules Souches Germinales, 92265, Fontenay-Aux-Roses, France.
A S GilleUniversité Paris-Saclay, CEA, UMR Stabilité Génétique Cellules Souches Et Radiations, iRCM/IBFJ, Laboratoire Des Cellules Souches Germinales, 92265, Fontenay-Aux-Roses, France.
I AllemandUniversité Paris-Saclay, CEA, UMR Stabilité Génétique Cellules Souches Et Radiations, iRCM/IBFJ, Laboratoire Des Cellules Souches Germinales, 92265, Fontenay-Aux-Roses, France.
L LenezTeam From Gametes To Birth. Departments Genetic and Cellular Plasticity. Metabolism and Endocrinology. Cochin Institute. INSERM U1016, Paris, France.
N ThiounnAP-HP. Center-University Paris Cité. Cochin Hospital, Paris, France.
S RouxAP-HP. Center-University Paris Cité. Cochin Hospital, Paris, France.
J P WolfTeam From Gametes To Birth. Departments Genetic and Cellular Plasticity. Metabolism and Endocrinology. Cochin Institute. INSERM U1016, Paris, France.
C PatratTeam From Gametes To Birth. Departments Genetic and Cellular Plasticity. Metabolism and Endocrinology. Cochin Institute. INSERM U1016, Paris, France.
L RiouUniversité Paris-Saclay, CEA, UMR Stabilité Génétique Cellules Souches Et Radiations, iRCM/IBFJ, Laboratoire Des Cellules Souches Germinales, 92265, Fontenay-Aux-Roses, France.
V Barraud-LangeTeam From Gametes To Birth. Departments Genetic and Cellular Plasticity. Metabolism and Endocrinology. Cochin Institute. INSERM U1016, Paris, France.
P FouchetUniversité Paris-Saclay, CEA, UMR Stabilité Génétique Cellules Souches Et Radiations, iRCM/IBFJ, Laboratoire Des Cellules Souches Germinales, 92265, Fontenay-Aux-Roses, France. pierre.fouchet@cea.fr.ORCID http://orcid.org/0000-0003-0891-079X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

About one in six couples experience fertility problems, and male infertility accounts for about half of these cases. Spermatogenesis originates from a small pool of spermatogonial stem cells (SSCs), which are of interest for the treatment of infertility but remain poorly characterised in humans. Using multiparametric spectral flow cytometric analysis with a 16-colours (16-C) panel of cell markers, we identify novel markers of SSCs and provide insights into unravelling and resolving the heterogeneity of the human spermatogonial cells. This 16-C panel of markers allowed the identification of a primitive SSCs state with the β2M

Indexed as

Flow CytometrySpermatogenesisSpermatogoniaAdultAdult Germline Stem CellsBiomarkersCell DifferentiationHumansIntegrin alpha6MaleStem CellsTestisBiomarkersIntegrin alpha6HumanSpectral cytometrySpermatogenesisSpermatogonial stem cell

Identifiers

PMID39725808
PMCPMC11671462

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.