Evidence map›Paper›PMID 39725767›Full record

ArticleBiogerontology2024

The mitochondrial and cytoplasmic superoxide anion imbalance trigger the expression of certain cellular aging markers in HaCaT keratinocytes.

Nathalia Cardoso de Afonso Bonotto, Ivana Beatrice Mânica da Cruz, Bárbara Osmarin Turra, Ana Laura Kerkhoff Escher, Fernanda Dos Santos Trombini, João Arthur B Zimmermann, Verônica Farina Azzolin, Micheli Mainardi Pillat, Euler Esteves Ribeiro-Filho, Fernanda Barbisan

Abstract read
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Article in Biogerontology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nathalia Cardoso de Afonso Bonotto *Postgraduate Program in Pharmacology, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil.
Ivana Beatrice Mânica da Cruz *Postgraduate Program in Pharmacology, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil. ivana.ufsm@gmail.com.
Bárbara Osmarin TurraPostgraduate Program in Gerontology, Center for Physical Education and Sports, Federal University of Santa Maria, Santa Maria, Brazil.
Ana Laura Kerkhoff EscherBiogenomics Laboratory, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil.
Fernanda Dos Santos TrombiniBiogenomics Laboratory, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil.
João Arthur B ZimmermannBiogenomics Laboratory, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil.
Verônica Farina AzzolinCenter for Research, Teaching and Technological Development, Open University Foundation for the Third Age, Manaus, Brazil.
Micheli Mainardi PillatPostgraduate Program in Pharmacology, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil.
Euler Esteves Ribeiro-FilhoCenter for Research, Teaching and Technological Development, Open University Foundation for the Third Age, Manaus, Brazil.
Fernanda BarbisanPostgraduate Program in Pharmacology, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In cells, the term "cellular aging" represents a collection of biological changes that can precede the proliferative senescence states. Cells more resistant to proliferative senescence, such as the ones found in the basal layer of the epidermis, may also exhibit these aging patterns. Therefore, cellular aging events could be induced by endogenous signals named here as cellular aging triggers (CATs) components. The superoxide anion (O

Indexed as

Cell ProliferationCellular SenescenceKeratinocytesMitochondriaParaquatSuperoxidesbeta-GalactosidaseBiomarkersCell LineCytoplasmHaCaT CellsHumansOxidative StressRotenoneTransforming Growth Factor betabeta-GalactosidaseBiomarkersParaquatRotenoneSuperoxidesTransforming Growth Factor betaCellular agingOxidative imbalanceParaquatRotenone

Identifiers

PMID39725767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.