ArticleMedical & biological engineering & computing2025
Evaluation of a cognition-sensitive spatial virtual reality game for Alzheimer's disease.
Article in Medical & biological engineering & computing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Review
- Virtual and Augmented Reality Games in Dementia Care: Systematic and Bibliographic Review.Healthcare (Basel, Switzerland) · 2025Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Spatial impairment characterizes Alzheimer's disease (AD) from its earliest stages. We present the design and preliminary evaluation of "Barn Ruins," a serious virtual reality (VR) wayfinding game for early-stage AD. Barn Ruins is tailored to the cognitive abilities of this population, featuring simple controls and error-based scoring system. Ten younger adults, ten cognitively healthy older adults, and ten age-matched individuals with AD participated in this study. They underwent cognitive assessments using the Montreal Cognitive Assessment (MoCA) and the Montgomery-Åsberg Depression Rating Scale (MADRS) before gameplay. The game involves navigating a virtual environment to find a target room, with increasing levels of difficulty. This study aimed to confirm the cognitive sensitivity of the Barn Ruins' spatial learning score by studying its relationship with Montreal Cognitive Assessment (MoCA) scores. MoCA scores and spatial learning scores had a correlation coefficient of 0.755 (p < 0.001). Logistic regression further revealed that higher spatial learning scores significantly predicted lower odds of cognitive impairment (OR = 0.495, 95% CI [0.274, 0.746], p < 0.005). The initial results suggest that the game is effective in differentiating performance among participant groups. This research demonstrates the potential of the Barn Ruins game as an innovative tool for assessing spatial navigation in AD, highlighting areas for future validation and investigation as a training tool.
Indexed as
Identifiers
39725762What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.