Evidence map›Paper›PMID 39725701›Full record

ArticleAnnals of hematology2025

Study on clinical features of early death in older patients with acute promyelocytic leukemia.

Yanqiu Zhao, Xinru Yu, Liru Yan, Deli Shi, Jinqiao Li, Wenyi Hou, Qisheng Zhang, Yuxin Zhu, Yingmei Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yanqiu Zhao *Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People's Republic of China.
Xinru Yu *Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People's Republic of China.
Liru YanDepartment of Developmental-Behavioral Pediatrics, The Sixth Affiliated Hospital of Harbin Medical University, Harbin, 150001, People's Republic of China.
Deli ShiDepartment of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People's Republic of China.
Jinqiao LiDepartment of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People's Republic of China.
Wenyi HouDepartment of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People's Republic of China.
Qisheng ZhangDepartment of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People's Republic of China.
Yuxin ZhuDepartment of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People's Republic of China.
Yingmei ZhangKey Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People's Republic of China. zhangyingmei@hrbmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to analyze the baseline clinical characteristics, as well as the clinical features and risk factors of early death (ED) in older patients with acute promyelocytic leukemia (APL). A retrospective analysis was conducted on 198 consecutive older patients (age ≥ 50 years) with newly diagnosed APL who received arsenic trioxide alone as induction therapy, with 354 younger patients (age < 50 years) as controls. Ten easily obtainable clinical parameters were selected. Compared with the younger group, the older group had less fever, lower white blood cell (WBC) count, lower levels of albumin, and higher levels of creatinine upon admission. While the younger group had higher levels of aspartate aminotransferase and lower levels of fibrinogen (all P < 0.05). The ED rate was significantly higher in the older group (21.7% vs. 12.4%; P = 0.004). The causes of ED in the older group were bleeding, infection, embolism, differentiation syndrome, and others, in order of incidence. The cumulative incidence of ED due to infection (P = 0.0003) and embolism (P = 0.034) was significantly higher in the older group. For the older patients, independent risk factors for ED were WBC count > 5.9 × 10

Indexed as

Leukemia, Promyelocytic, AcuteAdultAgedAged, 80 and overAge FactorsArsenic TrioxideFemaleHumansLeukocyte CountMaleMiddle AgedRetrospective StudiesRisk FactorsArsenic TrioxideAcute promyelocytic leukaemiaArsenic trioxideEarly deathOlder

Identifiers

PMID39725701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.