Evidence map›Paper›PMID 39725695›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

CD38-specific immunoPET imaging for multiple myeloma diagnosis and therapeutic monitoring: preclinical and first-in-human studies.

Wenpeng Huang, Tianyao Wang, Yongkang Qiu, Chenzhen Li, Bo Chen, Lele Song, Qi Yang, Xinyao Sun, Bing Jia, Lei Kang

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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Dual-tracer PET/CT with [European journal of nuclear medicine and molecular imaging · 2026
    Trial
  3. Article
  4. ICOS-Targeted Peptide Imaging Informs Therapeutic Response of STING Agonist in Lung Adenocarcinoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
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  5. [European journal of nuclear medicine and molecular imaging · 2026
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  7. Review
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  9. Affinity- and Format-Dependent Pharmacokinetics ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  10. Review
  11. Article
  12. ImmunoPET imaging of c-Met using a nanobody-based tracer [European journal of nuclear medicine and molecular imaging · 2025
    Article
  13. Article
  14. Article
  15. Noninvasive ImmunoPET imaging of PD-L1 expression in non-small cell lung cancer and bladder cancer using [Colloids and surfaces. A, Physicochemical and engineering aspects · 2025
    Article
  16. Incidental finding of subclinical cardiac involvement by [European journal of nuclear medicine and molecular imaging · 2025
    Article
  17. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wenpeng HuangDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 Xishiku Str., Xicheng Dist, Beijing, 100034, China.
Tianyao WangDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 Xishiku Str., Xicheng Dist, Beijing, 100034, China.
Yongkang QiuDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 Xishiku Str., Xicheng Dist, Beijing, 100034, China.
Chenzhen LiDepartment of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
Bo ChenChengdu AlpVHHs Co. Ltd, Chengdou, 611137, China.
Lele SongDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 Xishiku Str., Xicheng Dist, Beijing, 100034, China.
Qi YangDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 Xishiku Str., Xicheng Dist, Beijing, 100034, China.
Xinyao SunDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 Xishiku Str., Xicheng Dist, Beijing, 100034, China.
Bing JiaDepartment of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
Lei KangDepartment of Nuclear Medicine, Peking University First Hospital, No. 8 Xishiku Str., Xicheng Dist, Beijing, 100034, China. kanglei@bjmu.edu.cn.ORCID 0000-0001-8729-4547

Funding

Beijing Nova Program 20240484725China Postdoctoral Science Foundation under Grant Number 2024M750132National High Level Hospital Clinical Research Funding (Interdisciplinary Research Project of Peking University First Hospital, 2023IR17, 2024IR07National Natural Science Foundation of Chin 82171970, 82472018, 82402320Scientific and Technological Achievements Transformation Incubation Guidance Fund Project of Peking University First Hospital 2024CX20Scientific Research Seed Fund of Peking University First Hospital 2024SF64the Beijing Municipal Science & Technology Commission Z221100007422027the Beijing Science Foundation for Distinguished Young Scholars JQ21025
6 · The paper itself

Abstract

purposeCD38 is a glycoprotein highly specific to multiple myeloma (MM). Therapeutics using antibodies targeting CD38 have shown promising efficacy. However, the efficient stratification of patients who may benefit from daratumumab (Dara) therapy and timely monitoring of therapeutic responses remain significant clinical challenges. To address these issues, we developed a novel nanobody-based PET tracer, [ MATERIALS AND

methodsWe prepared a new PET imaging probe based on a CD38-targeted nanobody CD3813, [

resultsTOHP-CD3813 retained a high affinity for CD38 with a KD of 0.0826 nmol/L. [

conclusions[

Indexed as

ADP-ribosyl Cyclase 1Membrane GlycoproteinsMultiple MyelomaPositron-Emission TomographyAnimalsCell Line, TumorFemaleGallium RadioisotopesHumansMicePositron Emission Tomography Computed TomographySingle-Domain AntibodiesTissue DistributionADP-ribosyl Cyclase 1Gallium RadioisotopesMembrane GlycoproteinsSingle-Domain Antibodies68GaCD38First-in-humanMultiple myelomaNanobodyPositron emission tomography

Identifiers

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Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.