Evidence map›Paper›PMID 39725634›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[FER-1 inhibits methylglyoxal-induced ferroptosis in mouse alveolar macrophages

Qi Zhang, Zezhao Ji, Abai Jiashaer, Youda Wang, Abuduxukuer Abulimiti

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qi ZhangDepartment of Histology and Embryology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830000, China.
Zezhao JiDepartment of Histology and Embryology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830000, China.
Abai JiashaerDepartment of Histology and Embryology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830000, China.
Youda WangDepartment of Histology and Embryology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830000, China.
Abuduxukuer AbulimitiDepartment of Histology and Embryology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830000, China.

Funding

National Natural Science Foundation of China 32060158
6 · The paper itself

Abstract

objectivesTo investigate the inhibitory effect of FER-1 on methylglyoxal-induced ferroptosis in cultured mouse alveolar macrophages.

methodsMH-S cells derived from mouse alveolar macrophages treated with 90 μg/mL methylglyoxal, 10 μmol/mL FER-1MG+FER-1, or both were examined for intracellular reactive oxygen species (ROS), malondialdehyde (MDA) and ferrous ion (Fe

resultsMethylglyoxal treatment of MH-S cells for 24 h significantly decreased the protein expression level of GPX4, upregulated the protein expression of ACSL4, increased intracellular concentrations of ferrous ions, ROS and MDA, caused loss of mitochondrial membrane potential, and decreased cell viability. Treatment of the cells with FER-1 effectively attenuated these detrimental effects of methylglyoxal in MH-S cells by increasing GPX4 expression, reducing ACSL4 expression and intracellular ferrous ions, ROS and MDA levels, and restoring the mitochondrial membrane potential.

conclusionsMethylglyoxal can induce ferroptosis in MH-S cells in a dose-dependent manner, and FER-1 can rescue the cells from methylglyoxal-induced ferroptosis.

Indexed as

Coenzyme A LigasesFerroptosisMacrophages, AlveolarMembrane Potential, MitochondrialPhospholipid Hydroperoxide Glutathione PeroxidasePyruvaldehydeReactive Oxygen SpeciesAnimalsCell SurvivalMalondialdehydeMiceAcsl4 protein, mouseCoenzyme A Ligasesglutathione peroxidase 4, mouseMalondialdehydePhospholipid Hydroperoxide Glutathione PeroxidasePyruvaldehydeReactive Oxygen Speciesferroptosisferroptosis inhibitor ferroptin-1methylglyoxalmouse alveolar macrophages

Identifiers

PMID39725634
PMCPMC11683347

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.