Evidence map›Paper›PMID 39725618›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Protective effect of

Xiaoling Su, Daoyong Liao, Chao Li, Li Chen, Jingyun Wang, Tian Gan, Haodang Luo, Ning Wu, Jun He

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Low-Cost Protocol for Quantitative Measurement ofLife (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoling SuDepartment of Laboratory Medicine, Hengyang First People's Hospital, Hengyang 421001, China.
Daoyong LiaoDepartment of Laboratory Medicine, Hengyang First People's Hospital, Hengyang 421001, China.
Chao LiDepartment of Laboratory Medicine, Hengyang First People's Hospital, Hengyang 421001, China.
Li ChenDepartment of Laboratory Medicine, Hengyang First People's Hospital, Hengyang 421001, China.
Jingyun WangDepartment of Laboratory Medicine, Hengyang First People's Hospital, Hengyang 421001, China.
Tian GanDepartment of Laboratory Medicine, Hengyang First People's Hospital, Hengyang 421001, China.
Haodang LuoDepartment of Laboratory Medicine, Hengyang First People's Hospital, Hengyang 421001, China.
Ning WuClinical Laboratory, Hengyang First People's Hospital, Hengyang 421001, China.
Jun HeDepartment of Laboratory Medicine, Hengyang First People's Hospital, Hengyang 421001, China.

Funding

the Young Scientists Fund of the National Natural Science Foundation of China 82302567
6 · The paper itself

Abstract

objectivesTo investigate the protective effect of the probiotic bacterium

methodsForty male BALB/c mice were randomized into normal control group, K12 treatment group, Mp infection group, and K12 pretreatment prior to Mp infection group. The probiotic K12 was administered daily by gavage for 14 days before Mp infection induced by intranasal instillation of Mp. Three days after Mp infection, the mice were euthanized for analysis of bronchoalveolar lavage fluid (BALF) cell counts and serum levels of secretory immunoglobulin A (sIgA), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6). RT-qPCR was performed to detect the P1 and community-acquired respiratory distress syndrome ( CARDS ) toxin of Mp in the lung tissues and the mRNA expressions of TNF-α, IL-6, chemokine 1 (CXCL1), matrix metalloproteinase 9 (MMP9), mucin 5ac (MUC5ac), collagen 3a1 (Col3a1), Toll-like receptor 2 (TLR2) and TLR4; the protein expressions of TLR2 and TLR4 in the lung tissue were detected using Western blotting. Pathological changes in the lung tissue and airway remodeling were examined with HE staining and AB/PAS staining.

resultsCompared with the Mp-infected mice with PBS treatment, the infected mice with K12 treatment showed significantly lowered mRNA levels of P1 and CARDS in the lung tissue and reduced white blood cell counts in the BALF (

conclusionsK12 pretreatment can effectively reduce pulmonary inflammatory responses, improve airway remodeling and alleviate lung injury in Mp-infected mice.

Indexed as

Interleukin-6LungMice, Inbred BALB CMycoplasma pneumoniaePneumonia, MycoplasmaProbioticsStreptococcus salivariusToll-Like Receptor 2Toll-Like Receptor 4Tumor Necrosis Factor-alphaAnimalsBacterial ProteinsBacterial ToxinsBronchoalveolar Lavage FluidChemokine CXCL1Immunoglobulin A, SecretoryBacterial ProteinsBacterial ToxinsCARDS toxin, Mycoplasma pneumoniaeChemokine CXCL1Cxcl1 protein, mouseImmunoglobulin A, SecretoryInterleukin-6interleukin-6, mouseMatrix Metalloproteinase 9Mmp9 protein, mouseMuc5ac protein, mouseMucin 5ACTlr2 protein, mouseTlr4 protein, mouseToll-Like Receptor 2Toll-Like Receptor 4Tumor Necrosis Factor-alphaBALB/c miceMycoplasma pneumoniaeMycoplasma pneumoniae infection modeloral probioticsStreptococcus salivarius K12

Identifiers

PMID39725618
PMCPMC11683358

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.