Evidence map›Paper›PMID 39725438›Full record

ArticleBMJ open2024

Association between prenatal tobacco exposure and attention-deficit/hyperactivity disorder related characteristics at 6 and 8 years: a birth cohort in Japan.

Mariko Itoh, Sumitaka Kobayashi, Shinkichi Nishihara, Chihiro Miyashita, Keiko Yamazaki, Naomi Tamura, Satoshi Suyama, Atsuko Ikeda, Sachiko Itoh, Yu Ait Bamai and 4 more

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In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mariko ItohCenter for Environmental and Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
Sumitaka KobayashiCenter for Environmental and Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
Shinkichi NishiharaCenter for Environmental and Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
Chihiro MiyashitaCenter for Environmental and Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
Keiko YamazakiCenter for Environmental and Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
Naomi TamuraCenter for Environmental and Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
Satoshi SuyamaFunded Research Division of Child and Adolescent Psychiatry, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.
Atsuko IkedaCenter for Environmental and Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.ORCID http://orcid.org/0000-0002-3065-262X
Sachiko ItohCenter for Environmental and Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
Yu Ait BamaiCenter for Environmental and Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
Takeshi YamaguchiCenter for Environmental and Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.ORCID http://orcid.org/0000-0001-6329-0437
Hideyuki MasudaPharmaceutical Sciences, Musashino University, Nishitokyo, Tokyo, Japan.
Sharon HanleyDepartment of Academic Primary Care, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, AB25, 2ZB, Aberdeen, Scotland.
Reiko KishiCenter for Environmental and Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan rkishi@med.hokudai.ac.jp.ORCID http://orcid.org/0000-0001-8173-9269

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo examine the association between maternal plasma cotinine concentrations during pregnancy and attention-deficit/hyperactivity disorder (ADHD) related characteristics in children.

designProspective birth cohort study from the Hokkaido Study on Environment and Children's Health.

settingHokkaido, Japan.

participantsA total of 7217 children were included in the analysis. Their mothers were recruited to this study between 2003 and 2012 during early pregnancy. Blood samples of mothers in their third trimester of pregnancy were obtained.

main outcome measuresADHD-related characteristics screened by the ADHD-Rating Scale (ADHD-RS) in children at 6 and 8 years of age.

resultsThe mothers were classified into three groups according to plasma cotinine levels (median=0.22 ng/mL)-non-smokers (≤0.21 ng/mL), passive smokers (0.22-11.48 ng/mL) and active smokers (≥11.49 ng/mL). ADHD was suspected in 302 (8.6%), 334 (10.9%) and 90 (14.5%) children in the non-smoker, passive smoker and active smoker groups, respectively. Children born to mothers in the smoking group had a statistically significant increased risk of ADHD-related characteristics (adjusted RR=1.49, 95% CI=1.19-1.86 and adjusted RR=1.20, 95% CI=1.03-1.40 for the active and passive smoking groups, respectively).

conclusionThis large Japanese cohort study suggests an association between smoking during pregnancy and the risk of ADHD in children 6 and 8 years of age.

Indexed as

Attention Deficit Disorder with HyperactivityCotininePrenatal Exposure Delayed EffectsTobacco Smoke PollutionAdultBirth CohortChildFemaleHumansJapanMalePregnancyProspective StudiesRisk FactorsSmokingCotinineTobacco Smoke PollutionDevelopmental neurology & neurodisabilityEPIDEMIOLOGIC STUDIESPregnancyTobacco Use

Identifiers

PMID39725438
PMCPMC11683938

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.