ArticleThe Annals of thoracic surgery2025
Cannulation Configuration and Its Effects on Bridging to Lung Transplant: Analysis of the Extracorporeal Life Support Organization Registry.
Article in The Annals of thoracic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDonor stagnation and modification of lung allocation scores has resulted in a higher acuity of patient presentation before lung transplantation. Extracorporeal membrane oxygenation (ECMO) has been used as a bridge to lung transplant (BTT), although the effect of cannulation strategy on outcomes has not been well investigated. We analyzed contemporary data on ECMO BTT by using a large, international registry of patients.
methodsWe used the Extracorporeal Life Support Organization registry to identify all adult patients from 2010 to 2022 undergoing ECMO as a BTT. Patients were stratified by venovenous or venoarterial support type.
resultsA total of 1066 patients were identified. ECMO BTT increased over the study period (P < .001), as did survival to hospital discharge (P < .001), with an overall survival of 87.7%. Venovenous patients experienced fewer complications on ECMO, including dialysis (16.7% vs 25.3%, P = .006), stroke (1.4% vs 5.1%, P = .004), and limb ischemia (0.2% vs 3.4%, P < .001) and required ECMO less frequently in the postoperative period (41.0% vs 53.4%, P = .002) and for less time (4 days [interquartile range, 2-7 days] vs 5 days [interquartile range, 3-9 days], P = .01). In-hospital mortality was significantly lower for venovenous patients compared with venoarterial patients (11.0% vs 18.5%, P = .005). Increasing center volume of ECMO BTT was protective of in-hospital mortality (P < .001), with benefit observed after ∼45 total BTT intent cannulations.
conclusionsECMO BTT has resulted in improved posttransplant survival to discharge. Owing to a higher rate of complications and worsened mortality, thoughtful implementation of venoarterial ECMO in BTT should be undertaken when assessing patient candidacy.
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