Evidence map›Paper›PMID 39725250›Full record

Trial reportThe Annals of thoracic surgery2025

Causes of Death After Coronary Revascularization in Patients With Diabetes.

Lucas C Godoy, Valentin Fuster, Louai Razzouk, George Dangas, Sanjum S Sethi, Mandeep S Sidhu, Alfredo E Rodriguez, Scott D Solomon, Michael E Farkouh

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Annals of thoracic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lucas C GodoyPeter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada; Instituto do Coração (InCor), Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.
Valentin FusterZena and Michael Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Louai RazzoukLeon H. Charney Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York, New York.
George DangasZena and Michael Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Sanjum S SethiCenter for Interventional Vascular Therapy, Columbia University Irving Medical Center, New York, New York.
Mandeep S SidhuDivision of Cardiology, Department of Medicine, Albany Medical College and Albany Medical Center, Albany, New York.
Alfredo E RodriguezInterventional Cardiology, Otamendi Hospital, Buenos Aires, Argentina; Cardiovascular Research Center, Buenos Aires, Argentina.
Scott D SolomonDivision of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Michael E FarkouhCedars-Sinai Health System, Los Angeles, California. Electronic address: michael.farkouh@cshs.org.

Funding

Coronary Revascularization in Diabetic PatientsU01HL071988 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI FUSTER, VALENTIN · 2004 to 2011
$24.2M
NHLBI NIH HHS U01 HL071988
6 · The paper itself

Abstract

backgroundIn patients with diabetes and multivessel coronary artery disease, percutaneous coronary intervention (PCI) has been associated with higher long-term cardiovascular mortality compared with coronary artery bypass grafting (CABG), but the specific causes of death are not well known. We aimed to determine the causes of death of patients with diabetes and multivessel disease undergoing coronary revascularization with PCI vs CABG.

methodsWe analyzed the centrally adjudicated causes of death of 1900 participants in the FREEDOM trial. Cause-specific hazard ratios (csHRs) were used to compare mortality rates.

resultsThere were 197 deaths during the 5 years of follow-up; 63.5% were classified as cardiovascular deaths and the remaining (36.5%), noncardiovascular deaths. Sudden cardiac death was the most common cause of cardiovascular mortality (40% of all cardiovascular deaths), followed by myocardial infarction deaths (16% of all cardiovascular deaths). Compared with CABG, PCI was associated with increased ischemia-related mortality, namely, sudden cardiac death (csHR, 2.04; 95% CI, 1.13-3.70; P = .02) and the composite of sudden cardiac death and myocardial infarction death (csHR, 2.10; 95% CI, 1.27-3.48, P = .004). PCI was associated with a nonsignificant increase in overall cardiovascular mortality compared with CABG (csHR, 1.35; 95% CI, 0.95-1.93; P = .09).

conclusionsSudden cardiac death was the most common cause of long-term mortality of patients with diabetes and multivessel coronary artery disease undergoing a revascularization procedure. Compared with CABG, PCI was associated with increased long-term rates of ischemia-related mortality. Operative techniques and secondary prevention should target reducing post-revascularization spontaneous myocardial infarction in patients treated with PCI.

Indexed as

Coronary Artery BypassCoronary Artery DiseaseDiabetes MellitusPercutaneous Coronary InterventionAgedCause of DeathDeath, Sudden, CardiacFemaleFollow-Up StudiesHumansMaleMiddle AgedSurvival Rate

Identifiers

PMID39725250
PMCPMC12094902

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.