ArticleEnvironmental research2025
Genetic modifiers of asthma response to air pollution in children: An African ancestry GWAS and PM
Article in Environmental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic and environmental risk factors of asthma: a narrative review.Frontiers in immunology · 2026Pooled it
- From Susceptibility to Severity: The Impact of Interleukin-33 rs1929992 Polymorphism on Asthma in a Taiwanese Population.Life (Basel, Switzerland) · 2026Article
- Associations between genetic ancestry and allergic outcomes at 10 years among Black children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- A Narrative Review of Gene-Environment Interactions in Pediatric Pulmonology.Pediatric pulmonology · 2026Review
- Assessing the comorbidity between asthma and depression through polygenic risk scoring and time-to-event models.BMC medicine · 2026Article
- Genetic susceptibility to PMFrontiers in immunology · 2026Article
- The impact of prematurity on pediatric asthma morbidity and indices with environmental pollution and genetic susceptibility.Communications medicine · 2025Article
- Associations of Matrix Metalloproteinase-7 Promoter Genotypes With Asthma Risk in Taiwan.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
rationaleAmbient air pollution (AAP) is linked to asthma outcomes, but predicting individual risk remains challenging. Understanding genetic contributors to AAP sensitivity may help overcome this gap.
objectivesTo determine if single nucleotide polymorphisms (SNPs) are associated with AAP sensitivity in children with asthma.
methodsWe complete a GWAS in pediatric patients with asthma frequently exposed to AAP, comparing patients with exacerbations following spikes in AAP to patients without this temporal association and calculate a polygenic risk score (PRS) for PM MEASUREMENTS AND
resultsWe included 6023 patients in the GWAS, restricted to the African ancestry cohort due to the association between AAP exposure and race. Three loci reached genome-wide significance, including rs111970601, associated with CO sensitivity (odds ratio [OR] 6.58; P = 1.63 × 10
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Registered trials
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