Evidence map›Paper›PMID 39725035›Full record

ArticleThe Journal of biological chemistry2025

Human calpain-3 and its structural plasticity: Dissociation of a homohexamer into dimers on binding titin.

Qilu Ye, Amy Henrickson, Borries Demeler, Vitor Hugo Balasco Serrão, Peter L Davies

RetractedAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. RecurrentInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Qilu YeDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Amy HenricksonDepartment of Chemistry & Biochemistry, University of Lethbridge, Lethbridge, Alberta, Canada.
Borries DemelerDepartment of Chemistry & Biochemistry, University of Lethbridge, Lethbridge, Alberta, Canada.
Vitor Hugo Balasco SerrãoBiomolecular Cryo-Electron Microscopy Facility, University of California - Santa Cruz, Santa Cruz, California, United States; Department of Chemistry and Biochemistry, University of California - Santa Cruz, Santa Cruz, California, United States.
Peter L DaviesDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada. Electronic address: daviesp@queensu.ca.

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Development of an UltraScan Meta-Scheduler for HPC Job SubmissionR01GM120600 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Emre H. Brookes, BORRIES DEMELER · 2016 to 2026
$3.6M
Lightsheet Microscope for Large-Scale Imaging of Cleared Tissue SamplesS10OD025091 · OD · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2018 to 2018
$337k
NIGMS NIH HHS P30 GM124166NIGMS NIH HHS R01 GM120600NIGMS NIH HHS R01 GM129325NIGMS NIH HHS U24 GM129547NIH HHS S10 OD025091
6 · The paper itself

Abstract

Calpain-3 is an intracellular Ca

Indexed as

CalpainConnectinMuscle ProteinsProtein MultimerizationHumansProtein BindingCalpainCAPN3 protein, humanConnectinMuscle ProteinsTTN protein, humancalpaincalpain-3cryo-electron microscopymultimerizationprotein complextitin

Identifiers

PMID39725035
PMCPMC11795594

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.