ArticleThe Journal of allergy and clinical immunology2025
Early-life microRNA signatures in cord blood associated with allergic rhinitis and asthma development.
Article in The Journal of allergy and clinical immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The trial behind it
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Who cites it
5 citing papers in PubMed.
- MicroRNAs as Diagnostic and Therapeutic Biomarkers in Childhood Asthma: A Systematic Review with Bioinformatics Analysis.Journal of personalized medicine · 2026Review
- The Immunogenetic Landscape of Allergic Rhinitis: from Cellular Effectors to Gene Regulation and Targeted Therapies.International journal of biological sciences · 2026Review
- miRNA profiling shows shared signatures in pediatric asthma, obesity and their comorbidity.Frontiers in immunology · 2026Article
- MicroRNAs in Asthma: A Replication-Based Review of Human Evidence.Journal of inflammation research · 2026Review
- Neocnidilide and 6-Gingerol as Key Bioactives in Fresh and DriedInternational journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundMicroRNAs (miRNAs) are involved in the biological regulation of asthma and allergies.
objectiveWe sought to investigate the association between cord blood miRNAs and the development of allergic rhinitis and early childhood asthma.
methodsmiRNAs were sequenced from cord blood of subjects participating in the Vitamin D Antenatal Asthma Reduction Trial. Multivariable miRNA differential expression analyses were performed to examine their association with physician-diagnosed asthma and allergic rhinitis by age 3 years as well as active asthma status at age 6 years. miRNA signatures were further investigated for their ability to induce human airway smooth muscle cell proliferation in vitro.
resultsIn a cohort of 389 subjects, elevated cord blood expression of miR-149-5p was associated with both allergic rhinitis and asthma at age 3 years (log
conclusionsThe dysregulation of cord blood miRNAs at birth is associated with allergic rhinitis and early childhood asthma. The miRNAs that regulate postembryonic development and immune response may serve as potential biomarkers and preventive targets for asthma.
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Registered trials
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