Evidence map›Paper›PMID 39723836›Full record

ArticleJournal of clinical microbiology2025

Optimization and analytical validation of the Allplex HPV28 genotyping assay for use in first-void urine samples.

Margo Bell, Iacopo Baussano, MaryLuz Rol, Vanessa Tenet, Daniëlle A M Heideman, Tarik Gheit, Anne Van Caesbroeck, Alex Vorsters, Gary Clifford

Abstract readValidation Study
In one paragraph

Article in Journal of clinical microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Margo BellCentre for the Evaluation of Vaccination (CEV), Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Flanders, Belgium.ORCID 0000-0001-8032-5312
Iacopo BaussanoInternational Agency for Research on Cancer, Lyon, France.
MaryLuz RolInternational Agency for Research on Cancer, Lyon, France.
Vanessa TenetInternational Agency for Research on Cancer, Lyon, France.
Daniëlle A M HeidemanDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Groningen, the Netherlands.
Tarik GheitInternational Agency for Research on Cancer, Lyon, France.
Anne Van CaesbroeckCentre for the Evaluation of Vaccination (CEV), Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Flanders, Belgium.
Alex VorstersCentre for the Evaluation of Vaccination (CEV), Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Flanders, Belgium.
Gary CliffordInternational Agency for Research on Cancer, Lyon, France.

Funding

Bill and Melinda Gates Foundation (GF) 35537Bill and Melinda Gates Foundation (GF) OPP1053353EC | European Research Council (ERC) 101040588Fonds Wetenschappelijk Onderzoek (FWO) 11PJK24NUniversity of Antwerp (DOCPRO4-TT(ZAP)BOF) FN542300005World Health Organization 001
6 · The paper itself

Abstract

Despite first-void urine (FVU) being increasingly recognized as a credible specimen for human papillomavirus (HPV) detection, there is a lack of well-validated testing methods providing full quantitative genotyping required for vaccine impact monitoring from FVU samples. The Allplex HPV28 assay, capable of individually detecting 28 HPV genotypes, presents a promising method. We aimed to evaluate its genotype-specific performance on FVU samples, following optimization of FVU preanalytics. We selected 701 FVU samples collected using a Colli-Pee device (20 mL, with UCM), enriched for HPV-positivity (

Indexed as

Genotyping TechniquesPapillomaviridaePapillomavirus InfectionsUrineAdolescentAdultAlphapapillomavirusDNA, ViralFemaleGenotypeHumansMaleMiddle AgedSensitivity and SpecificityYoung AdultDNA, Viralfirst-void urineHPV genotypingself-samplingvaccine impact monitoring

Identifiers

PMID39723836
PMCPMC11837537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.