Evidence map›Paper›PMID 39723536›Full record

ArticleHypertension (Dallas, Tex. : 1979)2025

Reduced AT

Kelsey S Schwartz, Mingyao Sun, Diana I Jalal, Mark K Santillan, Anna E Stanhewicz

Registry-linked trialAbstract readClinical Trial, Phase I
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05937841 (Sensitivity of Angiotensin II Type II Receptors in Women Following Preeclampsia), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05937841 early_phase1recruitingnot on this map

Sensitivity of Angiotensin II Type II Receptors in Women Following Preeclampsia

TypeinterventionalSponsorAnna Stanhewicz, PhDRan2023 to 2026Enrolled30ConditionsPreeclampsia PostpartumArmsCompound 21
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Comparing cutaneous NO-dependent vasodilation between young males and females.medRxiv : the preprint server for health sciences · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kelsey S SchwartzDepartment of Health and Human Physiology, The University of Iowa (K.S.S., A.E.S.).ORCID 0000-0002-1418-1813
Mingyao SunDepartment of Internal Medicine (M.S., D.I.J.), Carver College of Medicine, Iowa City, IA.ORCID 0000-0003-3513-4298
Diana I JalalThe Iowa City Veterans Affairs Healthcare System (D.I.J.).ORCID 0000-0002-1975-8650
Mark K SantillanDepartment of Obstetrics and Gynecology (M.K.S.), Carver College of Medicine, Iowa City, IA.ORCID 0000-0003-4082-7582
Anna E StanhewiczDepartment of Health and Human Physiology, The University of Iowa (K.S.S., A.E.S.).ORCID 0000-0002-3941-3879

Funding

University of Iowa Institute for Clinical and Translational ScienceUM1TR004403 · NCATS · UNIVERSITY OF IOWA · PI Marlan R Hansen, Patricia Winokur · 2023 to 2026
$16.1M
PROGRAM IN HEMOSTASIS AND THROMBOSIS FOR ACADEMICT32HL007344 · NHLBI · UNIVERSITY OF IOWA · PI Anil Kumar Chauhan, Steven R Lentz · 1985 to 2026
$6.5M
Role of Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclamptic PregnancyR00HL138133 · NHLBI · UNIVERSITY OF IOWA · PI STANHEWICZ, ANNA · 2019 to 2021
$747k
NCATS NIH HHS UM1 TR004403NHLBI NIH HHS R00 HL138133NHLBI NIH HHS T32 HL007344
6 · The paper itself

Abstract

backgroundWomen who had preeclampsia (a history of preeclampsia) have a >4-fold risk of developing cardiovascular disease compared with women who had an uncomplicated pregnancy (history of healthy pregnancy). Despite the remission of clinical symptoms after pregnancy, vascular endothelial dysfunction persists postpartum, mediated in part by exaggerated Ang II (angiotensin II)-mediated constriction. However, the role of vasodilatory AT

methodsOverall, 24 women (n=12/group) participated. We measured cutaneous vascular conductance responses to (1) graded infusion of compound 21 (AT

resultsAT

conclusionsReductions in AT REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05937841.

Indexed as

Endothelium, VascularPre-EclampsiaReceptor, Angiotensin, Type 2VasodilationAdultFemaleHumansPregnancySignal TransductionReceptor, Angiotensin, Type 2angiotensin IIendotheliummicrocirculationpre-eclampsiapregnancyreceptor, angiotensin, type 2

Identifiers

PMID39723536
PMCPMC12003086

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.