Evidence map›Paper›PMID 39723343›Full record

ArticleClinical, cosmetic and investigational dermatology2024

Combination Therapy with Baricitinib and Narrowband Ultraviolet B for Active Non-Segmental Vitiligo: A Retrospective Controlled Study.

Bin Zhou, Jiachen Gui, Tao Wang, Zhimin Li, Wenzhi Hu, Yue Zhang, Qiang Li

Abstract read
In one paragraph

Article in Clinical, cosmetic and investigational dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Oral JΑΚ Inhibitors in Vitiligo Treatment.Dermatology and therapy · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bin ZhouGraduate School, Hebei North University, Zhangjiakou, People's Republic of China.ORCID 0009-0008-0703-2239
Jiachen GuiDepartment of Dermatology, Air Force Medical Center, PLA, Beijing, People's Republic of China.
Tao WangDepartment of Dermatology, Air Force Medical Center, PLA, Beijing, People's Republic of China.
Zhimin LiDepartment of Dermatology, Air Force Medical Center, PLA, Beijing, People's Republic of China.
Wenzhi HuDepartment of Burn and Plastic Surgery, the Air Force Medical Center of Air, Force Military Medical University of Chinese PLA, Beijing, People's Republic of China.
Yue ZhangDepartment of Dermatology, Air Force Medical Center, PLA, Beijing, People's Republic of China.ORCID 0000-0001-9461-6233
Qiang LiDepartment of Dermatology, Air Force Medical Center, PLA, Beijing, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vitiligo is a chronic autoimmune disease manifested by depigmented patches of skin devoid of melanocytes. Baricitinib, a JAK inhibitor selectively targeting JAK1/2, has shown preliminary efficacy for vitiligo. We aimed to assess the efficacy and tolerability of combination therapy with baricitinib and narrowband UV-B (NB-UVB) to treat active nonsegmental vitiligo (NSV). Methods: We formed a combination group of 52 patients with NSV receiving baricitinib and NB-UVB irradiation, and a control group of 49 patients with NSV receiving oral mini-pulse (OMP) methylprednisolone and NB-UVB irradiation. Efficacy analysis was conducted for the 6-month period. Six months after the last treatment, the recurrence rates were investigated through follow-up. Results: From the first month, the mean total vitiligo area scoring index (VASI) score was significantly reduced in the combination group when compared to that in the control group. Starting on the fourth month, the overall response rates (ORRs) were significantly higher in the combination group than in the control group ( Conclusion: Our observations suggest that the combination therapy with baricitinib and NB-UVB is a promising strategy against NSV. Patients tolerated the treatment well without serious AEs, these results expand treatment options for vitiligo patients, warranting larger clinical trials.

Indexed as

assessmentautoimmune diseaseefficacyre-pigmentationsafety

Identifiers

PMID39723343
PMCPMC11668684

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.