Evidence map›Paper›PMID 39723294›Full record

ArticleCureus2024

Lung Adenocarcinoma and Peripheral Blood Eosinophilia.

Margarida I Pereira, Carolina Saca, Mónica Lopes, Inês Eiriz, Andreia Chaves

Abstract readCase Reports
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Margarida I PereiraPulmonology, Hospital Professor Doutor Fernando Fonseca, Lisbon, PRT.
Carolina SacaInternal Medicine, Hospital Professor Doutor Fernando Fonseca, Lisbon, PRT.
Mónica LopesInternal Medicine, Hospital Professor Doutor Fernando Fonseca, Lisbon, PRT.
Inês EirizMedical Oncology, Hospital Professor Doutor Fernando Fonseca, Lisbon, PRT.
Andreia ChavesMedical Oncology, Hospital Professor Doutor Fernando Fonseca, Lisbon, PRT.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are many causes of peripheral blood eosinophilia (PBE), including allergic, infectious, rheumatic, and hematologic disorders. Solid tumor cancers, such as lung cancer, can also cause PBE, and although rare, being diagnosed with PBE in this way is associated with a worse prognosis than for lung cancer patients without PBE. Additionally, some cancer patients develop PBE when receiving treatment with immune checkpoint inhibitors (ICIs). When PBE is caused in this way, the outcome varies. On the one hand, there are reports of severe adverse events, while on the other, ICIs-induced PBE may be a predictive biomarker of better outcomes. This article reports on the case of a 66-year-old male patient with metastatic lung adenocarcinoma presenting with paraneoplastic hypereosinophilia aggravated by pembrolizumab.

Indexed as

immune-checkpoint inhibitor adverse effectsmetastatic non-small cell lung cancerparaneoplastic syndromesperipheral eosinophiliaprimary lung adenocarcinoma

Identifiers

PMID39723294
PMCPMC11669050

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.